Document Detail


Autophagy modulation as a potential therapeutic target for diverse diseases.
MedLine Citation:
PMID:  22935804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.
Authors:
David C Rubinsztein; Patrice Codogno; Beth Levine
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature reviews. Drug discovery     Volume:  11     ISSN:  1474-1784     ISO Abbreviation:  Nat Rev Drug Discov     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-31     Completed Date:  2012-11-05     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101124171     Medline TA:  Nat Rev Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  709-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy / drug effects*,  physiology
Communicable Diseases / drug therapy,  epidemiology
Drug Delivery Systems / methods*,  trends
Humans
Neurodegenerative Diseases / drug therapy,  epidemiology
Pharmaceutical Preparations / administration & dosage*
Signal Transduction / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
089703//Wellcome Trust; 095317//Wellcome Trust; G0600194//Medical Research Council; MC_G1000734//Medical Research Council; R01 CA109618/CA/NCI NIH HHS; R01 CA109618/CA/NCI NIH HHS; U54 AI057156/AI/NIAID NIH HHS; U54AI057156/AI/NIAID NIH HHS; //Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations
Comments/Corrections

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