| Autophagy and lipids: tightening the knot. | |
| | |
MedLine Citation:
|
PMID: 20730586 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The degradation of intracellular components in lysosomes, also known as autophagy, participates in a broad range of cellular functions from cellular quality control to cellular remodeling or as mechanism of defense against cellular aggressors. In this review, we focus on the role of autophagy as an alternative source of cellular energy, particularly important when nutrients are scarce. Almost since the discovery of autophagy, it has been known that amino acids obtained through the breakdown of proteins in lysosomes are essential to maintaining the cellular energetic balance during starvation. However, it is only recently that the ability of autophagy to mobilize intracellular lipid stores as an additional source of energy has been described. Autophagy contributes thus to modulating the amount of cellular lipids and allows cells to adapt to lipogenic stimuli. Interestingly, this interplay between autophagy and lipid metabolism is bidirectional, as changes in the intracellular lipid content also contribute to modulating autophagic activity. In this review, we describe the recent findings on the contribution of autophagy to lipid metabolism in different tissues and the consequences that impairments in autophagy have on cellular physiology. In addition, we comment on the regulatory role that lipid molecules and their modifying enzymes play on different steps of the autophagic process. |
| | |
Authors:
|
Jose Antonio Rodriguez-Navarro; Ana Maria Cuervo |
Related Documents
:
|
18406356 - Negative regulation of apoptosis in yeast. 19242106 - An executioner caspase regulates autophagy. 7849526 - The molecular mechanisms of neuronal apoptosis. 18632846 - Mechanisms of renal apoptosis in health and disease. 21530676 - Distinctive and critical roles for cellular immunity and immune-inflammatory response i... 2622096 - Enhancing effect of antitumor polysaccharide from astragalus or radix hedysarum on c3 c... |
Publication Detail:
|
Type: Journal Article Date: 2010-08-22 |
Journal Detail:
|
Title: Seminars in immunopathology Volume: 32 ISSN: 1863-2300 ISO Abbreviation: Semin Immunopathol Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101308769 Medline TA: Semin Immunopathol Country: Germany |
Other Details:
|
Languages: eng Pagination: 343-53 Citation Subset: IM |
Affiliation:
|
Department of Developmental and Molecular Biology and Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, New York, NY, 10461, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bone mineral density in the femoral neck increases after hip resurfacing: a cohort with five-year fo...
Next Document: Isolation and functional characterization of a waterlogging-induced promoter from maize.