Document Detail

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity.
MedLine Citation:
PMID:  22465415     Owner:  NLM     Status:  MEDLINE    
Our previous study revealed that resveratrol blocks prion protein peptide PrP(106-126)-induced neurotoxicity. However, the mechanism of resveratrol-mediated neuroprotection in prion diseases is not clear. Resveratrol initiates neuroprotective effects via the activation of autophagy, which protects organelles, cells, and organisms against misfolded protein-disorders, including Alzheimer's disease and Parkinson's disease via regulation of mitochondrial homeostasis. Thus, we focused on elucidating the mechanisms responsible for resveratrol-mediated neuroprotection related to mitochondrial homeostasis as a result of autophagy activation. Resveratrol prevented PrP(106-126)-induced neuronal cell death by activating autophagy. Moreover, resveratrol-induced autophagy prevented the PrP(106-126)-induced reduction in mitochondrial potential and translocation of Bax to the mitochondria and cytochrome c release. Our results indicate that treatment with resveratrol appears to protect against neurotoxicity caused by prion protein peptides and the neuroprotection is induced by resveratrol-mediated autophagy signals.
Jae-Kyo Jeong; Myung-Hee Moon; Bum-Chul Bae; You-Jin Lee; Jae-Won Seol; Hyung-Sub Kang; Jin-Shang Kim; Seog-Jin Kang; Sang-Youel Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-23
Journal Detail:
Title:  Neuroscience research     Volume:  73     ISSN:  1872-8111     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2013-02-19     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Korea Zoonoses Research Institute, Bio-Safety Research Institute, Center for Healthcare Technology Development, College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, South Korea.
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MeSH Terms
Autophagy / drug effects*,  physiology
Cell Line, Tumor
Mitochondria / drug effects,  physiology
Neuroprotective Agents / pharmacology*
Peptide Fragments / antagonists & inhibitors,  toxicity*
Prions / antagonists & inhibitors,  toxicity*
Stilbenes / pharmacology*
Reg. No./Substance:
0/Neuroprotective Agents; 0/Peptide Fragments; 0/Prions; 0/Stilbenes; 0/prion protein (106-126); Q369O8926L/resveratrol

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