Document Detail


Autophagy in the filamentous fungus Aspergillus fumigatus.
MedLine Citation:
PMID:  19185725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many breakthroughs in our understanding of the function and molecular basis of autophagy have been achieved in mammalian and yeast systems. However, we still know very little about the contribution of autophagy to the biology of filamentous fungi. A comparative analysis of autophagy between genera will expand our knowledge of the autophagy machinery and has the potential to identify novel functions that are relevant to multiple biological systems. This chapter will discuss methods that have been employed for studying autophagy in the opportunistic mold pathogen Aspergillus fumigatus. Understanding how autophagy influences the growth of this important human pathogen could lead to the development of novel antifungal drugs that restrict the growth of the fungus by manipulating the autophagy pathway.
Authors:
Daryl L Richie; David S Askew
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  451     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-03-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-50     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, USA.
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MeSH Terms
Descriptor/Qualifier:
Aspergillus fumigatus / cytology,  physiology*
Autophagy / physiology*
Biological Assay / methods*
Cell Culture Techniques
Culture Media / chemistry
Fungal Proteins / genetics,  metabolism
Humans
Chemical
Reg. No./Substance:
0/Culture Media; 0/Fungal Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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