Document Detail

Autophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential Therapeutic Targets.
MedLine Citation:
PMID:  25140315     Owner:  NLM     Status:  Publisher    
Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis. Alcohol consumption leads to injury in various tissues and organs including liver, pancreas, heart, brain, and muscle. Emerging evidence suggests that autophagy is involved in alcohol-induced tissue injury. Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury in most tissues but could be detrimental in heart and muscle. This review summarizes current knowledge about the role of autophagy in alcohol-induced injury in different tissues/organs and its potential molecular mechanisms as well as possible therapeutic targets based on modulation of autophagy.
Yuan Li; Shaogui Wang; Hong-Min Ni; Heqing Huang; Wen-Xing Ding
Related Documents :
18346235 - Measurement of forelimb function by digital video motion analysis in rat nerve transect...
8724465 - Restoration of sensibility in the hand after complete brachial plexus injury.
18068175 - The free diffusion of macromolecules in tissue-engineered skeletal muscle subjected to ...
20851075 - Tarsal tunnel syndrome and flexor hallucis longus tendon hypertrophy.
24551845 - The evidence for nerve repair in obstetric brachial plexus palsy revisited.
23942175 - Low vitamin d status is associated with reduced muscle mass and impaired physical perfo...
Publication Detail:
Type:  REVIEW     Date:  2014-7-17
Journal Detail:
Title:  BioMed research international     Volume:  2014     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2014  
Date Detail:
Created Date:  2014-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  498491     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Speech understanding with a new implant technology: a comparative study with a new nonskin penetrati...
Next Document:  Intracochlear Fluid Pressure Changes Related to the Insertional Speed of a CI Electrode.