Document Detail


Autophagy in Alcohol-Induced Multiorgan Injury: Mechanisms and Potential Therapeutic Targets.
MedLine Citation:
PMID:  25140315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis. Alcohol consumption leads to injury in various tissues and organs including liver, pancreas, heart, brain, and muscle. Emerging evidence suggests that autophagy is involved in alcohol-induced tissue injury. Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury in most tissues but could be detrimental in heart and muscle. This review summarizes current knowledge about the role of autophagy in alcohol-induced injury in different tissues/organs and its potential molecular mechanisms as well as possible therapeutic targets based on modulation of autophagy.
Authors:
Yuan Li; Shaogui Wang; Hong-Min Ni; Heqing Huang; Wen-Xing Ding
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Publication Detail:
Type:  REVIEW     Date:  2014-7-17
Journal Detail:
Title:  BioMed research international     Volume:  2014     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2014  
Date Detail:
Created Date:  2014-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  498491     Citation Subset:  -    
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