Document Detail


Autophagy fights disease through cellular self-digestion.
MedLine Citation:
PMID:  18305538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health.
Authors:
Noboru Mizushima; Beth Levine; Ana Maria Cuervo; Daniel J Klionsky
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  451     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-03-31     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  1069-75     Citation Subset:  IM    
Affiliation:
Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Autophagy / immunology,  physiology*
Cell Death
Cell Survival
Humans
Immunity, Innate / immunology
Neoplasms / pathology
Neurodegenerative Diseases / pathology
Grant Support
ID/Acronym/Agency:
R01 AG021904-06/AG/NIA NIH HHS; R03 AG019834-02/AG/NIA NIH HHS; R21 AG025355-02/AG/NIA NIH HHS
Comments/Corrections

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