| Autophagy fights disease through cellular self-digestion. | |
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MedLine Citation:
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PMID: 18305538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health. |
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Authors:
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Noboru Mizushima; Beth Levine; Ana Maria Cuervo; Daniel J Klionsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature Volume: 451 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-28 Completed Date: 2008-03-31 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 1069-75 Citation Subset: IM |
Affiliation:
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Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Autophagy / immunology, physiology* Cell Death Cell Survival Humans Immunity, Innate / immunology Neoplasms / pathology Neurodegenerative Diseases / pathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG021904-06/AG/NIA NIH HHS; R03 AG019834-02/AG/NIA NIH HHS; R21 AG025355-02/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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