Document Detail


Autophagy as a mechanism of radiation sensitization in breast tumor cells.
MedLine Citation:
PMID:  17204856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current studies to define the mechanism by which vitamin D3 and analogs of vitamin D3 enhance the response to ionizing radiation in breast tumor cells suggest that these effects are mediated, in large part, through the promotion of autophagic cell death. The residual surviving cell population remains in a senescent, growth arrested state, with minimal recovery of proliferative capacity. It is becoming evident that pathways other than or in addition to apoptosis, including senescence arrest, mitotic catastrophe and autophagy, contribute to loss of self-renewal capacity in tumor cells exposed to chemotherapeutic drugs and ionizing radiation. How and why the cell chooses a particular growth arrest and/or cell death pathway remains a puzzle to be solved.
Authors:
David A Gewirtz
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Publication Detail:
Type:  Journal Article     Date:  2007-05-19
Journal Detail:
Title:  Autophagy     Volume:  3     ISSN:  1554-8627     ISO Abbreviation:  Autophagy     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-50     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Virginia 23298, USA. gewirtz@hsc.vcu.edu
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Autophagy*
Breast Neoplasms / drug therapy*,  pathology,  radiotherapy*
Cell Line, Tumor
Cholecalciferol / analogs & derivatives,  therapeutic use*
Humans
Radiation, Ionizing*
Chemical
Reg. No./Substance:
67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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