| Autophagy as a mechanism of radiation sensitization in breast tumor cells. | |
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MedLine Citation:
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PMID: 17204856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current studies to define the mechanism by which vitamin D3 and analogs of vitamin D3 enhance the response to ionizing radiation in breast tumor cells suggest that these effects are mediated, in large part, through the promotion of autophagic cell death. The residual surviving cell population remains in a senescent, growth arrested state, with minimal recovery of proliferative capacity. It is becoming evident that pathways other than or in addition to apoptosis, including senescence arrest, mitotic catastrophe and autophagy, contribute to loss of self-renewal capacity in tumor cells exposed to chemotherapeutic drugs and ionizing radiation. How and why the cell chooses a particular growth arrest and/or cell death pathway remains a puzzle to be solved. |
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Authors:
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David A Gewirtz |
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Publication Detail:
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Type: Journal Article Date: 2007-05-19 |
Journal Detail:
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Title: Autophagy Volume: 3 ISSN: 1554-8627 ISO Abbreviation: Autophagy Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-03-27 Completed Date: 2007-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 249-50 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Virginia Commonwealth University, Massey Cancer Center, Virginia 23298, USA. gewirtz@hsc.vcu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis Autophagy* Breast Neoplasms / drug therapy*, pathology, radiotherapy* Cell Line, Tumor Cholecalciferol / analogs & derivatives, therapeutic use* Humans Radiation, Ionizing* |
| Chemical | |
Reg. No./Substance:
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67-97-0/Cholecalciferol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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