| Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies. | |
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MedLine Citation:
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PMID: 19855186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. We have recently shown that dexamethasone induces autophagy in lymphoid leukemia cells and in this particular setting this cell death modality is a prerequisite for the efficient killing of the leukemic cells by dexamethasone. Hence, inhibition of autophagy by siRNA-mediated silencing of Beclin 1, as well as chemical inhibition of type III PtdIns3K, inhibits apoptosis, demonstrating an important role of autophagy in dexamethasone-induced cell death. In this brief report, we review these findings and introduce the multiple myeloma cells as a novel system to study autophagy in response to dexamethasone. |
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Authors:
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Dan Grand?r; Pedram Kharaziha; Edward Laane; Katja Pokrovskaja; Theocharis Panaretakis |
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Publication Detail:
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Type: Journal Article Date: 2009-11-18 |
Journal Detail:
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Title: Autophagy Volume: 5 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 1198-200 Citation Subset: IM |
Affiliation:
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Department of Oncology/Pathology, Cancer Centre Karolinska R8:03, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Annexin A5
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metabolism Apoptosis / drug effects* Autophagy / drug effects* Dexamethasone / pharmacology* Glucocorticoids / pharmacology* Hematologic Neoplasms / pathology* Humans Propidium / metabolism Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Glucocorticoids; 36015-30-2/Propidium; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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