| Autophagy: an affair of the heart. | |
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MedLine Citation:
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PMID: 23188163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Whether an element of routine housekeeping or in the setting of imminent disaster, it is a good idea to get one's affairs in order. Autophagy, the process of recycling organelles and protein aggregates, is a basal homeostatic process and an evolutionarily conserved response to starvation and other forms of metabolic stress. Our understanding of the role of autophagy in the heart is changing rapidly as new information becomes available. This review examines the role of autophagy in the heart in the setting of cardioprotection, hypertrophy, and heart failure. Contradictory findings are reconciled in light of recent developments. The preponderance of evidence favors a beneficial role for autophagy in the heart under most conditions. |
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Authors:
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Roberta A Gottlieb; Robert M Mentzer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-28 |
Journal Detail:
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Title: Heart failure reviews Volume: - ISSN: 1573-7322 ISO Abbreviation: Heart Fail Rev Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612481 Medline TA: Heart Fail Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA, USA, RGottlieb@mail.sdsu.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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