Document Detail

Autophagy, Senescence, and Apoptosis.
MedLine Citation:
PMID:  23150435     Owner:  NLM     Status:  Publisher    
This chapter presents methods for interrogating the involvement of p53 in signaling to apoptosis, autophagy, and senescence. The well-known association of p53 with the stress response to chemotherapy and radiation is the basis for presenting these approaches. The development of quantitative and efficient in vitro assays has enabled researchers to overcome the limitations of previous methodologies. This chapter provides up-to-date procedures relating to the molecular networks in which the p53 protein has been shown to play a central role that allows damaged cells either to adapt to stress (autophagy and/or senescence) or to progress towards programmed cell death (apoptosis).
Rachel W Goehe; Molly L Bristol; Eden N Wilson; David A Gewirtz
Related Documents :
19427865 - Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases no(.) and p...
21314975 - Spi-1-encoded type iii secretion system of salmonella enterica is required for the supp...
18712755 - Response of hek293 and cho cells overexpressing fusiogenic syncytin-1 to mitochondrion-...
23889175 - Xenobiotic-induced apoptosis: significance and potential application as a general bioma...
22483925 - Ftir microspectroscopy discriminates anticancer action on human leukemic cells by extra...
24452475 - Atractylenolide-i sensitizes human ovarian cancer cells to paclitaxel by blocking activ...
Publication Detail:
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  962     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  31-48     Citation Subset:  -    
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Detecting p53 Isoforms at Protein Level.
Next Document:  p53 and Cell Cycle Effects After DNA Damage.