| Autophagy protects the proximal tubule from degeneration and acute ischemic injury. | |
| | |
MedLine Citation:
|
PMID: 21493778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autophagy is a bulk protein degradation system that likely plays an important role in normal proximal tubule function and recovery from acute ischemic kidney injury. Using conditional Atg5 gene deletion to eliminate autophagy in the proximal tubule, we determined whether autophagy prevents accumulation of damaged proteins and organelles with aging and ischemic renal injury. Autophagy-deficient cells accumulated deformed mitochondria and cytoplasmic inclusions, leading to cellular hypertrophy and eventual degeneration not observed in wildtype controls. In autophagy-deficient mice, I/R injury increased proximal tubule cell apoptosis with accumulation of p62 and ubiquitin positive cytoplasmic inclusions. Compared with control animals, autophagy-deficient mice exhibited significantly greater elevations in serum urea nitrogen and creatinine. These data suggest that autophagy maintains proximal tubule cell homeostasis and protects against ischemic injury. Enhancing autophagy may provide a novel therapeutic approach to minimize acute kidney injury and slow CKD progression. |
| | |
Authors:
|
Tomonori Kimura; Yoshitsugu Takabatake; Atsushi Takahashi; Jun-ya Kaimori; Isao Matsui; Tomoko Namba; Harumi Kitamura; Fumio Niimura; Taiji Matsusaka; Tomoyoshi Soga; Hiromi Rakugi; Yoshitaka Isaka |
Related Documents
:
|
8604998 - Thiophosphate induces apoptosis in human leukemia cell lines. 16952408 - Thymopentin (tp5), an immunomodulatory peptide, suppresses proliferation and induces di... 11295108 - Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia molt 4b cells. 3861308 - The effect of retinoids on haemopoiesis--clinical and laboratory studies. 18060088 - Enhanced leishmania braziliensis infection following pre-exposure to sandfly saliva. 21622168 - The role of mirnas in cytokine signaling. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-14 |
Journal Detail:
|
Title: Journal of the American Society of Nephrology : JASN Volume: 22 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: 2011-07-01 Revised Date: 2012-05-01 |
Medline Journal Info:
|
Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 902-13 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 by the American Society of Nephrology |
Affiliation:
|
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Kidney Injury
/
prevention & control* Animals Autophagy* Hypertrophy Kidney / blood supply*, pathology Kidney Tubules, Proximal / pathology* Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins / physiology Reperfusion Injury / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Atg5 protein, mouse; 0/Microtubule-Associated Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.
Next Document: Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infecti...