Document Detail


Autophagy, myocardial protection, and the metabolic syndrome.
MedLine Citation:
PMID:  22472909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.
Authors:
Zoltan Giricz; Robert M Mentzer; Roberta A Gottlieb
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  60     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2012-12-26     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Affiliation:
Department of Biology, Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182-4650, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy*
Energy Metabolism*
Humans
Ischemic Preconditioning, Myocardial*
Metabolic Syndrome X / complications*,  metabolism,  pathology
Myocardial Reperfusion Injury / etiology,  metabolism,  pathology,  prevention & control*
Myocardium / metabolism,  pathology*
Stress, Physiological
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
R01 AG033283/AG/NIA NIH HHS; R01 HL034579/HL/NHLBI NIH HHS; R01 HL060590/HL/NHLBI NIH HHS
Comments/Corrections

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