| Autophagic cell death exists. | |
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MedLine Citation:
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PMID: 22652592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The term autophagic cell death (ACD) initially referred to cell death with greatly enhanced autophagy, but is increasingly used to imply a death-mediating role of autophagy, as shown by a protective effect of autophagy inhibition. In addition, many authors require that autophagic cell death must not involve apoptosis or necrosis. Adopting these new and restrictive criteria, and emphasizing their own failure to protect human osteosarcoma cells by autophagy inhibition, the authors of a recent Editor's Corner article in this journal argued for the extreme rarity or nonexistence of autophagic cell death. We here maintain that, even with the more stringent recent criteria, autophagic cell death exists in several situations, some of which were ignored by the Editor's Corner authors. We reject their additional criterion that the autophagy in ACD must be the agent of ultimate cell dismantlement. And we argue that rapidly dividing mammalian cells such as cancer cells are not the most likely situation for finding pure ACD. |
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Authors:
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Peter G H Clarke; Julien Puyal |
Publication Detail:
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Type: Comment; Editorial; Research Support, Non-U.S. Gov't Date: 2012-06-01 |
Journal Detail:
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Title: Autophagy Volume: 8 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-08-24 Completed Date: 2013-01-03 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 867-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy* Humans |
| Comments/Corrections | |
Comment On:
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Autophagy. 2012 Jan;8(1):1-3
[PMID:
22082964
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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