Document Detail


Autophagic cell death exists.
MedLine Citation:
PMID:  22652592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The term autophagic cell death (ACD) initially referred to cell death with greatly enhanced autophagy, but is increasingly used to imply a death-mediating role of autophagy, as shown by a protective effect of autophagy inhibition. In addition, many authors require that autophagic cell death must not involve apoptosis or necrosis. Adopting these new and restrictive criteria, and emphasizing their own failure to protect human osteosarcoma cells by autophagy inhibition, the authors of a recent Editor's Corner article in this journal argued for the extreme rarity or nonexistence of autophagic cell death. We here maintain that, even with the more stringent recent criteria, autophagic cell death exists in several situations, some of which were ignored by the Editor's Corner authors. We reject their additional criterion that the autophagy in ACD must be the agent of ultimate cell dismantlement. And we argue that rapidly dividing mammalian cells such as cancer cells are not the most likely situation for finding pure ACD.
Authors:
Peter G H Clarke; Julien Puyal
Publication Detail:
Type:  Comment; Editorial; Research Support, Non-U.S. Gov't     Date:  2012-06-01
Journal Detail:
Title:  Autophagy     Volume:  8     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2013-01-03     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy*
Humans
Comments/Corrections
Comment On:
Autophagy. 2012 Jan;8(1):1-3   [PMID:  22082964 ]

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