Document Detail


Autonomous nervous system with respect to dressing of cattle carcasses and its probable role in transfer of PrP(res) molecules.
MedLine Citation:
PMID:  12747703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pathogen prions are widely recognized as the causative agent in bovine spongiform encephalopathy (BSE) and other transmissible spongiform encephalopathies. However, more research on the possible transmission mutes of this agent once it has reached the host is needed. There is evidence based on the anatomy and physiology of the autonomous nervous system (ANS), as well as observations for different animal species, that the ANS might be involved in the axonal drainage of pathogen prions toward the central nervous system. In this context, more attention should be paid to the cranial cervical ganglion, the stellate ganglion, the chain of paravertebral ganglia next to the first six thoracic vertebrae, the chain of the paravertebral ganglia next to loin vertebrae 1 through 6, the vagus nerve in the neck region and in the mediastine, and the esophagus (because of its close connection to the vagus nerve). For a more detailed risk analysis with respect to these tissues, the ANSs of animals having shown clinical signs of BSE might be examined to corroborate the evidence presented here. In the meantime, as a precautionary measure, the tissue addressed should be taken out of the human food chain, taken out of animal feed, and handled as if it were specified risk material. It is technically possible to remove these parts during cutting and dressing.
Authors:
R Fries; T Eggers; G Hildebrandt; K Rauscher; S Buda; K D Budras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of food protection     Volume:  66     ISSN:  0362-028X     ISO Abbreviation:  J. Food Prot.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-15     Completed Date:  2003-07-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703944     Medline TA:  J Food Prot     Country:  United States    
Other Details:
Languages:  eng     Pagination:  890-5     Citation Subset:  IM    
Affiliation:
Institute of Meat Hygiene, Free University of Berlin, Bruemmerstrasse 10, D 14195 Berlin, Germany. fries@zedat.fu-berlin.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / anatomy & histology*,  physiology*
Cattle
Consumer Product Safety
Encephalopathy, Bovine Spongiform / transmission
Food Chain
Humans
PrPSc Proteins / metabolism*
Prion Diseases / transmission*
Zoonoses
Chemical
Reg. No./Substance:
0/PrPSc Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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