Document Detail

Autonomic side effects of Botulinum toxin Type B intravesical injections: report of 4 cases and review of the literature.
MedLine Citation:
PMID:  17136583     Owner:  NLM     Status:  MEDLINE    
Recently, intravesical injections of Botulinum toxin type B (BT-B) have been trialled in an attempt to treat detrusor overactivity. Use of Botulinum toxin A (BT.-A), for the same in the past, has been quite successful without many reported side effects. Soon after commencing the clinical use of BT-B, a side effect profile was noticed not reported with BT-A. A total of 20 patients with refractory detrusor overactivity were included in this randomized, double blind, placebo controlled, cross over trial. As per protocol, 5000 MU (1 ml) BT-B diluted to a volume of 20 mls with normal saline were injected in 10 different sites into the detrusor, sparing the trigone. We report four cases of autonomic side effects after these injections which strongly suggest clinically relevant systemic spread of the toxin.
M Ghei; B H Maraj; S Nathan; J Malone-Lee; R Miller
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International urology and nephrology     Volume:  38     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2006  
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-09-07     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  543-4     Citation Subset:  IM    
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MeSH Terms
Administration, Intravesical
Autonomic Nervous System Diseases / chemically induced*
Botulinum Toxins / administration & dosage*,  pharmacology*
Middle Aged
Reg. No./Substance:
0Y70779M1F/rimabotulinumtoxinB; EC Toxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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