| Autonomic regulation during mild therapeutic hypothermia in cardiopulmonary resuscitated patients. | |
| | |
MedLine Citation:
|
PMID: 21476071 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: We investigated whether there are differences in autonomic cardiovascular regulation in resuscitated patients undergoing therapeutic hypothermia (TH) in relation to the clinical outcome. METHOD: Between 2005 and 2007, 18 consecutive resuscitated patients were enrolled. ECG and blood pressure data were recorded for 48 h during hypothermia and warming up to a body core temperature of 36°C. Autonomic regulation was assessed by applying time, frequency, and non-linear dynamics domain methods from heart rate and blood pressure variability (HRV/BPV) analyses. RESULTS: Nine patients survived with good neurological recovery, and nine patients died during the ICU stay. In both groups, we found a decreased HRV presented by standard deviation of R-R intervals (sdNN) below 50 ms(2) at each time of measurement. Immediately after recovery to a body core temperature of 36°C, a significant higher HRV was found in survivors compared to non-survivors by means of indices sdNN (40.2 ± 19.5 vs. 10.9 ± 4.1 ms(2), P = 0.01), R-R intervals distribution histogram [shannon] (3.7 ± 0.6 vs. 2.2 ± 0.4, P = 0.008), very low frequency band [VLF] (152.2 ± 99.3 vs. 3.4 ± 1.9, P = 0.001) and the variance of the time series of R-R intervals [Wsdvar] (1.16 ± 0.52 vs. 0.29 ± 0.25, P = 0.02) . A decreased spontaneous BPV was found only among survivors comparing blood pressure characteristics within stable hypothermia to the initial state before hypothermia. CONCLUSION: Resuscitated patients show a significantly reduced HRV before, during and after TH. Compared to survivors, the non-survivors show a further and significantly decrease of HRV immediately after hypothermia. |
| | |
Authors:
|
R Pfeifer; J Hopfe; C Ehrhardt; M Goernig; H R Figulla; A Voss |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
|
Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: - ISSN: 1861-0692 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Internal Medicine I, University Hospital Jena, Erlanger Allee 101, 07740, Jena, Germany, Ruediger.Pfeifer@med.uni-jena.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Computational investigation on the structure-activity relationship of the biradical mechanism for mo...
Next Document: An axonal strain injury criterion for traumatic brain injury.