Document Detail


Autonomic reactivity to sensory stimulation is related to consciousness level after severe traumatic brain injury.
MedLine Citation:
PMID:  16793340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine changes in the activity of the autonomic nervous system (ANS) that are related to recovery to consciousness in the post-acute phase after severe traumatic brain injury (sTBI). METHODS: Skin conductance and heart rate reactivity to sensory stimulation were recorded every 2 weeks for an average period of 3.5 months in 16 adolescent patients, during the assessment of their level of consciousness (LoC), and their cognitive and functional behaviour. RESULTS: Both heart rate variability (HRV) and skin conductance level (SCL) in reaction to sensory stimulation changed with recovery to consciousness. Indices of HRV and SCL that represent sympathetic activity of the autonomic nervous system (ANS) increased with recovery, whereas indices that represent parasympathetic activity decreased. In addition, we observed an increase in sympathovagal balance of the ANS with recovery. CONCLUSIONS: Recovery to consciousness determined by clinical observation in sTBI in the post-acute phase is related to changes in SCL and HRV during sensory stimulation. ANS reactivity to environmental stimulation can therefore give objective supplementary information about the clinical state of sTBI patients, and can contribute to decision-making in the treatment policy of unresponsive patients. SIGNIFICANCE: These findings demonstrate that autonomic reactivity can be informative concerning how a severely damaged nervous system reacts to environmental stimulation and how, in a recovering nervous system, this reactivity changes.
Authors:
Viona J M Wijnen; Matagne Heutink; Geert J M van Boxtel; Henk J Eilander; Beatrice de Gelder
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-21
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  117     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-26     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1794-807     Citation Subset:  IM    
Affiliation:
Cognitive Neuroscience Laboratory, Department of Psychology and Health, Tilburg University, Warandelaan 2, p.o. Box 90153, 5000 LE, Tilburg, The Netherlands. v.j.m.wijnen@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autonomic Nervous System / physiopathology*
Brain Injuries / physiopathology*
Consciousness / physiology*
Female
Galvanic Skin Response / physiology
Heart Rate / physiology
Humans
Male
Physical Stimulation
Recovery of Function

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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