Document Detail

Autonomic reactivity to mental stressors after single administration of lorazepam in male alcoholics and healthy controls.
MedLine Citation:
PMID:  11093970     Owner:  NLM     Status:  MEDLINE    
Clinically unaffected sons of male alcoholics differ from controls without a family history of alcoholism in two respects: increased autonomic reactivity to aversive as well as non-aversive stimuli and increased attenuation of these responses by alcohol. This pattern of autonomic hyper-reactivity and alcohol-induced stress response dampening (SRD) might be a trait marker of genetic vulnerability and is often interpreted in terms of a diathesis stress model of alcohol dependence. Forty-five alcohol-dependent men (mean age: 39.20 years) and 37 healthy controls (mean age: 35.03 years) participated in a double-blind cross-over study in two experimental sessions each. The benzodiazepine lorazepam was selected as an alcohol substitute. Autonomic reactivity and lorazepam-induced SRD were assessed during incentive and non-incentive reaction time tasks as well as mental arithmetics. Alcohol-dependent men showed elevated resting heart rate levels and increased number of non-specific electrodermal responses. Evidence for autonomic hyper-reactivity was found for a subgroup of alcoholics with a family history of alcoholism.
R Demmel; F Rist; R Olbrich
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  35     ISSN:  0735-0414     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  IM    
Psychological Institute I, University of Muenster, Fliednerstr. 21, 48149 Muenster, Germany.
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MeSH Terms
Alcoholism / genetics,  physiopathology*,  psychology
Analysis of Variance
Anti-Anxiety Agents / therapeutic use*
Arousal / drug effects,  genetics
Autonomic Nervous System / drug effects*
Case-Control Studies
Cross-Over Studies
Double-Blind Method
Lorazepam / therapeutic use*
Mental Processes / drug effects
Monitoring, Physiologic
Reaction Time / drug effects,  genetics
Stress, Psychological / genetics
Reg. No./Substance:
0/Anti-Anxiety Agents; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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