Document Detail

Autonomic and pharmacological control of oxygen autoregulation mechanisms in brain tissue.
MedLine Citation:
PMID:  1015419     Owner:  NLM     Status:  MEDLINE    
The effect of several agents active on autonomic nervous system functions was tested on brain oxygen autoregulation parameters. It was found that atropine, propranolol and isproterenol had no influence on the measured parameters. Phenoxybenzamine, tolazoline and dibenamine all suppress autoregulation. In an additional experimental series, a phenoxybenzamine infusion was given during O2 breathing. The infusion induced a marked rise in TpO2. It is concluded that an alpha-adrenergic mechanism is part of the autoregulation process, and its pharmacological blockade could be used to raise TpO2 levels in brain with O2 breathing at normal atmospheric pressure. Also, the increase in brain TpO2 induced by 95% O2 - 5% CO2 breathing seems to be blocked by alpha-adrenolytic drugs.
H I Bicher; P Marvin; D Hunt; D F Bruley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  75     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1976  
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  383-9     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Autonomic Agents / pharmacology*
Brain / metabolism*
Cerebrovascular Circulation / drug effects*
Dibenzylchlorethamine / pharmacology
Isoproterenol / pharmacology
Oxygen / blood
Oxygen Consumption / drug effects*
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Tolazoline / pharmacology
Reg. No./Substance:
0/Autonomic Agents; 51-50-3/Dibenzylchlorethamine; 51-55-8/Atropine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 59-98-3/Tolazoline; 7683-59-2/Isoproterenol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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