Document Detail

Autonomic neuropathy in hemodialysis patients treated with recombinant human erythropoietin.
MedLine Citation:
PMID:  8946232     Owner:  NLM     Status:  MEDLINE    
Autonomic nervous system (ANS) function was evaluated in hemodialysis patients treated with recombinant human erythropoietin (rHu-EPO) before and after therapy, in an effort to evaluate the role of anemia in the genesis of autonomic dysfunction in chronic renal failure (CRF). Studies were conducted using a battery of five cardiovascular reflex tests: Valsalva maneuver, handgrip exercise, heart rate response to standing (30:15 index), post-Valsalva rise in blood pressure and postural drop in blood pressure. The patients were divided into two groups: group I consisted of 14 patients on maintenance hemodialysis treated with rHu-EPO for one year, and group II-13 hemodialysis patients treated with rHu-EPO for two years. The results of the tests were compared before and after the correction of anemia by rHu-EPO in each group, as well as with the control group of ten healthy subjects. Data show that renal anemia is not implicated in the genesis of ANS dysfunction in hemodialysis patients, since correction of same by rHu-EPO does not improve the autonomic dysfunction.
O O Stojcheva-Taneva; M H Polenakovic
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  19     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-27     Completed Date:  1997-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  574-7     Citation Subset:  IM    
Department of Nephrology, Faculty of Medicine, University of Skopje, Macedonia.
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MeSH Terms
Autonomic Nervous System / drug effects*
Blood Pressure / drug effects
Electrocardiography / drug effects
Erythropoietin / administration & dosage,  pharmacology,  therapeutic use*
Heart Rate / drug effects
Injections, Subcutaneous
Kidney Failure, Chronic / drug therapy,  therapy*
Middle Aged
Recombinant Proteins / administration & dosage,  pharmacology,  therapeutic use*
Renal Dialysis*
Valsalva Maneuver
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

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