Document Detail

Autonomic neural control of cardiac rhythm: the role of autonomic imbalance in the genesis of cardiac dysrhythmia.
MedLine Citation:
PMID:  975122     Owner:  NLM     Status:  MEDLINE    
Cardiac dysrhythmias result from abnormalities in rate, regularity, or sequence of cardiac activation, and because of direct actions of the autonomic nervous system upon each of these properties, imbalance in this system may play an important role in the genesis of cardiac dysrhythmia. A canine model has been developed in which the extrinsic innervation of the heart is ablated with the exception of the ventrolateral cardiac nerve. This nerve is distributed primarily to the inferior atrial, AV junctional, and ventricular tissues. Following recovery from surgery, the animal is placed on a treadmill and required to perform strenuous exercise. In all of six animals which sustained repeated exercise testing over periods of 4-12 months, dysrhythmias of varying complexities were elicited. None appeared in parallel experiments conducted in control or sham-operated animals. The dysrhythmias consisted of supraventricular, AV junctional, or ventricular tachycardias with occasional premature atrial or ventricular systoles. The dysrhythmias were not influenced by atropine but were generally controlled by propranolol.
W C Randall; D E Euler; H K Jacobs; W Wehrmacher; M P Kaye; G R Hageman
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiology     Volume:  61     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1976  
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  20-36     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology*
Atropine / pharmacology
Autonomic Nervous System / physiology*
Blood Pressure
Electric Stimulation
Heart / innervation
Heart Conduction System / drug effects,  physiology*
Heart Rate* / drug effects
Models, Biological
Physical Exertion
Propranolol / pharmacology
Stellate Ganglion / physiology
Sympathetic Nervous System / physiology
Vagus Nerve / physiology
Reg. No./Substance:
51-55-8/Atropine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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