Document Detail

Autonomic nervous system function in rheumatoid arthritis. A controlled study.
MedLine Citation:
PMID:  8895145     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study cardiovascular autonomic nervous functions in patients with rheumatoid arthritis (RA) compared with controls and to investigate fasting and meal stimulated pancreatic polypeptide (PP) in RA and its possible associations with autonomic functions and disease activity. METHODS: Forty-three women meeting the American Rheumatism Association 1987 diagnostic criteria for RA and 61 healthy controls were studied. Blood pressure recordings and cardiovascular heart rate studies were performed. PP was measured by radioimmunoassay. RESULTS: Cardiovascular reflexes were equal in the 2 groups, but the patients had significantly higher fasting plasma PP level with mean log10 value of 0.94 pmol/l (SD = 0.38) compared with 0.68 pmol/l (SD = 0.35) in the controls (p = 0.0006). Mean log10 plasma PP increase 30 min after the meal was 1.80 pmol/l (SD = 0.42) for the patient group and 1.47 pmol/l (SD = 0.40) in the controls (p = 0.0001). Feeding caused a mean PP increase of 1.85 (SD = 0.42) for the patients and 1.44 (SD = 0.42) in the controls 60 min postprandially (p = 0.0001). Multiple regression and correlation analysis showed no association between PP and disease activity. CONCLUSION: The higher basal and postprandial PP in the RA group indicates a relationship between the disease and PP by unknown mechanisms.
S I Bekkelund; R Jorde; G Husby; S I Mellgren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  23     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1710-4     Citation Subset:  IM    
Department of Neurology, University Hospital, Tromsø, Norway.
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MeSH Terms
Arthritis, Rheumatoid / blood,  physiopathology*
Autonomic Nervous System / physiopathology*
Blood Pressure / physiology
Eating / physiology
Fasting / blood
Heart Rate / physiology
Middle Aged
Pancreatic Polypeptide / blood*
Valsalva Maneuver / physiology
Reg. No./Substance:
59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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