Document Detail

Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.
MedLine Citation:
PMID:  8410008     Owner:  NLM     Status:  MEDLINE    
Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.
J G van Dijk; J Haan; K Zwinderman; B Kremer; B J van Hilten; R A Roos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  56     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-19     Completed Date:  1993-11-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1090-5     Citation Subset:  IM    
Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Age Factors
Aged, 80 and over
Antiparkinson Agents / therapeutic use
Autonomic Nervous System Diseases / etiology,  physiopathology*
Blood Pressure / drug effects,  physiology
Confounding Factors (Epidemiology)
Heart Rate / drug effects,  physiology
Middle Aged
Parkinson Disease / complications*,  drug therapy,  physiopathology
Regression Analysis
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Antiparkinson Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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