Document Detail

Autonomic nervous system, circadian rhythms, and primary open-angle glaucoma.
MedLine Citation:
PMID:  15325194     Owner:  NLM     Status:  MEDLINE    
The etiology of primary open-angle glaucoma (POAG) remains the subject of continuing investigation. Despite the many known risk factors and mechanism of damage, the principal treatment objectives in POAG still consist of reduction of intraocular pressure, which although straightforward in many cases, often leaves the clinician with the question of how far to pursue a sufficiently low pressure to prevent further damage. Other risk factors such as hemodynamic insufficiency due to vascular dysregulation and abnormal blood pressure are often overlooked in the day-to-day practice; their harmful effects for glaucoma are, it seems, more potent at night while the patient sleeps and when clinical investigation is most difficult. Although the status of autonomic nervous system is an important determinant of the systemic hemodynamic parameters, this issue is usually ignored by the clinician in the process of glaucoma diagnosis. Consequently, there is a lack of alternative therapies tailored to address associated systemic risk factors for POAG on a case and chronological basis; this approach could be more effective in preventing the progression and visual loss in selected glaucoma cases.
Doina Gherghel; Sarah L Hosking; Selim Orgül
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Survey of ophthalmology     Volume:  49     ISSN:  0039-6257     ISO Abbreviation:  Surv Ophthalmol     Publication Date:    2004 Sep-Oct
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-11-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404551     Medline TA:  Surv Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  491-508     Citation Subset:  IM    
Neuroscience Research Institute, Aston University, Aston Triangle, Birmingham, United Kingdom.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Blood Pressure
Circadian Rhythm*
Glaucoma, Open-Angle / complications,  physiopathology*
Heart Rate
Intraocular Pressure
Sleep Apnea Syndromes / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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