| Autonomic nervous system, circadian rhythms, and primary open-angle glaucoma. | |
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MedLine Citation:
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PMID: 15325194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiology of primary open-angle glaucoma (POAG) remains the subject of continuing investigation. Despite the many known risk factors and mechanism of damage, the principal treatment objectives in POAG still consist of reduction of intraocular pressure, which although straightforward in many cases, often leaves the clinician with the question of how far to pursue a sufficiently low pressure to prevent further damage. Other risk factors such as hemodynamic insufficiency due to vascular dysregulation and abnormal blood pressure are often overlooked in the day-to-day practice; their harmful effects for glaucoma are, it seems, more potent at night while the patient sleeps and when clinical investigation is most difficult. Although the status of autonomic nervous system is an important determinant of the systemic hemodynamic parameters, this issue is usually ignored by the clinician in the process of glaucoma diagnosis. Consequently, there is a lack of alternative therapies tailored to address associated systemic risk factors for POAG on a case and chronological basis; this approach could be more effective in preventing the progression and visual loss in selected glaucoma cases. |
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Authors:
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Doina Gherghel; Sarah L Hosking; Selim Orgül |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Survey of ophthalmology Volume: 49 ISSN: 0039-6257 ISO Abbreviation: Surv Ophthalmol Publication Date: 2004 Sep-Oct |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2004-11-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0404551 Medline TA: Surv Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 491-508 Citation Subset: IM |
Affiliation:
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Neuroscience Research Institute, Aston University, Aston Triangle, Birmingham, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autonomic Nervous System
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physiopathology* Blood Pressure Circadian Rhythm* Glaucoma, Open-Angle / complications, physiopathology* Heart Rate Humans Intraocular Pressure Sleep Apnea Syndromes / complications |
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