Document Detail


Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration.
MedLine Citation:
PMID:  10916719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aims of this study were to assess autonomic nervous function in subjects with recently diagnosed Parkinson's disease (de novo patients) and to evaluate its changes following acute levodopa administration. In 13 patients (8 males, 5 females) and 13 age-matched control subjects, three cardiovascular autonomic function tests (Deep Breathing, Valsalva, Lying to Standing) were performed, the QT interval was calculated on a 12-lead electrocardiogram, and the response of plasma norepinephrine to standing was assessed in basal conditions. The cardiovascular tests and the measurement of the QT interval were repeated in de novo Parkinsonian patients 90 minutes after the administration of levodopa 200 mg per os. The results of the Deep Breathing and Valsalva tests were worse and the QT interval longer in patients than in control subjects (although the differences were not statistically significant). The heart rate increase at 30 seconds after standing up was significantly higher in Parkinsonian patients than in the control group. The response of plasma norepinephrine to standing was similar in both groups. Levodopa administration produced a slight improvement in the Deep Breathing test, a shortening of the QT interval and increased tachycardia on standing. Our data suggest that a mild subclinical impairment of parasympathetic function can be a feature of de novo Parkinsonian patients and that levodopa therapy could have a beneficial effect on this autonomic dysfunction.
Authors:
R Quadri; I Comino; L Scarzella; P Cacioli; M M Zanone; A Pipieri; B Bergamasco; L Chiandussi
Related Documents :
17260339 - Abnormal temporal discrimination threshold in patients with multiple system atrophy.
22398059 - Induction of psoriasis with anti-tnf agents in patients with inflammatory bowel disease...
22203939 - Gingival inflammatory infiltrate analysis in patients with chronic periodontitis and di...
12832009 - Classifying lower limb dynamics in parkinson's disease.
16920079 - Bradykinesia in patients with essential tremor.
20666719 - Hyperhomocysteinemia in l-dopa treated patients with parkinson's disease: potential imp...
2975949 - Lack of effect of warfarin on the restenosis rate or on clinical outcome after balloon ...
18350629 - Portal hemodynamics as predictors of high risk esophageal varices in cirrhotic patients.
9249639 - Prevalence of amlodipine-related gingival hyperplasia.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Functional neurology     Volume:  15     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2000 Apr-Jun
Date Detail:
Created Date:  2000-12-01     Completed Date:  2000-12-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Affiliation:
Department of Medicine and Experimental Oncology, San Vito Hospital, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antiparkinson Agents / administration & dosage,  pharmacology,  therapeutic use*
Chromatography, High Pressure Liquid
Drug Administration Schedule
Female
Heart Function Tests
Heart Rate / drug effects,  physiology*
Humans
Hypertension / diagnosis*,  physiopathology
Levodopa / administration & dosage,  pharmacology,  therapeutic use*
Long QT Syndrome / complications,  diagnosis
Male
Middle Aged
Norepinephrine / blood
Parkinson Disease / complications,  drug therapy*,  physiopathology*
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Can a 3-day preceptorship change first-year medical students' opinions about living and working in s...
Next Document:  Migraine as a complex disease: heterogeneity, comorbidity and genotype-phenotype interactions.