| Autonomic nervous function in de novo parkinsonian patients in basal condition and after acute levodopa administration. | |
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MedLine Citation:
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PMID: 10916719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aims of this study were to assess autonomic nervous function in subjects with recently diagnosed Parkinson's disease (de novo patients) and to evaluate its changes following acute levodopa administration. In 13 patients (8 males, 5 females) and 13 age-matched control subjects, three cardiovascular autonomic function tests (Deep Breathing, Valsalva, Lying to Standing) were performed, the QT interval was calculated on a 12-lead electrocardiogram, and the response of plasma norepinephrine to standing was assessed in basal conditions. The cardiovascular tests and the measurement of the QT interval were repeated in de novo Parkinsonian patients 90 minutes after the administration of levodopa 200 mg per os. The results of the Deep Breathing and Valsalva tests were worse and the QT interval longer in patients than in control subjects (although the differences were not statistically significant). The heart rate increase at 30 seconds after standing up was significantly higher in Parkinsonian patients than in the control group. The response of plasma norepinephrine to standing was similar in both groups. Levodopa administration produced a slight improvement in the Deep Breathing test, a shortening of the QT interval and increased tachycardia on standing. Our data suggest that a mild subclinical impairment of parasympathetic function can be a feature of de novo Parkinsonian patients and that levodopa therapy could have a beneficial effect on this autonomic dysfunction. |
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Authors:
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R Quadri; I Comino; L Scarzella; P Cacioli; M M Zanone; A Pipieri; B Bergamasco; L Chiandussi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Functional neurology Volume: 15 ISSN: 0393-5264 ISO Abbreviation: Funct. Neurol. Publication Date: 2000 Apr-Jun |
Date Detail:
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Created Date: 2000-12-01 Completed Date: 2000-12-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707746 Medline TA: Funct Neurol Country: ITALY |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: IM |
Affiliation:
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Department of Medicine and Experimental Oncology, San Vito Hospital, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antiparkinson Agents / administration & dosage, pharmacology, therapeutic use* Chromatography, High Pressure Liquid Drug Administration Schedule Female Heart Function Tests Heart Rate / drug effects, physiology* Humans Hypertension / diagnosis*, physiopathology Levodopa / administration & dosage, pharmacology, therapeutic use* Long QT Syndrome / complications, diagnosis Male Middle Aged Norepinephrine / blood Parkinson Disease / complications, drug therapy*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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