| Autonomic nerves in experimental allergic neuritis in the rat. | |
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MedLine Citation:
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PMID: 3875206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After experimental allergic neuritis (EAN) was induced in 16 male Lewis rats with bovine peripheral myelin and adjuvants, peripheral nerves were examined morphologically at intervals of 12-21 days post inoculation (dpi). Signs of motor involvement were present in ten rats and were first elicited 12 dpi. They ranged from tail droop to complete lower limb paralysis. Autonomic nervous system (ANS) involvement was studied by contrasting morphological findings in the cervical sympathetic nerves (CSN), which are poorly myelinated and vagal nerves (VN) which contain numerous myelinated fibers in the endoneurium. Edema, perivenular infiltrates, and demyelination appeared in the VN of seven of nine neurologically affected rats, while the CSN showed edema and infiltrates in only one rat. ELISA assays were negative for anti-galactocerebroside antibody, and electron microscopy failed to show abnormalities of Schwann cells. |
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Authors:
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M K Morey; C A Wiley; R A Hughes; H C Powell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Acta neuropathologica Volume: 67 ISSN: 0001-6322 ISO Abbreviation: Acta Neuropathol. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-09-23 Completed Date: 1985-09-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0412041 Medline TA: Acta Neuropathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 75-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / analysis Autonomic Nervous System / pathology* Enzyme-Linked Immunosorbent Assay Galactosylceramides / immunology Male Neck / innervation Neuritis, Autoimmune, Experimental / pathology* Rats Rats, Inbred Lew Sympathetic Nervous System / pathology Vagus Nerve / pathology |
| Grant Support | |
ID/Acronym/Agency:
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NS-14162/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Galactosylceramides |
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