Document Detail

Autonomic nerve function in adults with cyclic vomiting syndrome: a prospective study.
MedLine Citation:
PMID:  20667005     Owner:  NLM     Status:  In-Process    
BACKGROUND: Cyclic vomiting syndrome (CVS) is a functional gastrointestinal disorder that is characterized by recurrent episodes of intense vomiting. There are several postulated mechanisms involved in its pathogenesis and one potential explanation for this disorder may be linked to autonomic dysfunction. The aim of our study was to evaluate autonomic nerve function in patients with CVS prospectively.
METHODS: We tested the sympathetic nervous system through postural changes in heart rate (HR) and blood pressure and the thermoregulatory sweat test. The parasympathetic nervous system was tested through the HR response to deep breathing (R-R variability on EKG).
KEY RESULTS: A total of 20 patients who met Rome III criteria for CVS, 14 (70%) women and 6 (30%) men, and 20 controls were enrolled in the study. A total of 17 (85%) CVS subjects and 2 (10%) controls had abnormalities on thermoregulatory sweat testing (P < 0.001). A total of 7 (35%) patients and one control subject had evidence of postural tachycardia (P = 0.04) with an increase in HR > 30 on standing. Of the subjects, 18 (90%) had either abnormal sudomotor function or postural tachycardia or both. The HR response to deep breathing was normal in 19 (95%) subjects with CVS and 18 (95%) controls.
CONCLUSIONS & INFERENCES: The results of this study suggest that the majority of subjects (90%) with CVS have impairment of the sympathetic nervous system with postural tachycardia and/or sudomotor dysfunction while parasympathetic nerve function appears to be intact. These findings of dysautonomia in CVS have implications in both the diagnosis and treatment of these patients.
T Venkatesan; T Prieto; A Barboi; B Li; A Schroeder; W Hogan; A Ananthakrishnan; S Jaradeh
Related Documents :
9748015 - Denervation of eccrine glands in patients with familial amyloidotic polyneuropathy type i.
1324425 - Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascula...
21541455 - Leptospirosis-associated acute kidney injury.
12934025 - Prevalence of peripheral neurologic injuries in rotator cuff tears with atrophy.
22416185 - Predictability of outcome of caustic ingestion by esophagogastroduodenoscopy in children.
24782215 - Urinary nerve growth factor levels could be a biomarker for overactive bladder symptom:...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  22     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  1303-7, e339     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Comment In:
Neurogastroenterol Motil. 2011 Jan;23(1):109   [PMID:  21138501 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential responding of autonomic function to histamine H? antagonism in irritable bowel syndrome...
Next Document: