| Autonomic modulation of ultradian blood pressure and heart rate oscillations in dogs. | |
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MedLine Citation:
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PMID: 2566283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autonomic receptor modulation of ultradian oscillations of blood pressure and heart rate was studied in telemetered free-running dogs. Data, analyzed for their harmonic content by fast Fourier transform (FFT) methods, indicated that ultradian and circadian oscillations of 22.9 +/- 2.5 and 10.5 +/- 0.9 (SD) mmHg, respectively, were present. The average principal frequency for the ultradian oscillations in 12 dogs was 0.760 +/- 0.11 cycles/h for arterial pressure and 0.808 +/- 0.10 for heart rate. Atropine had no effect on periodicity of either arterial pressure or heart rate. Metoprolol, a beta 1-antagonist, or hexamethonium, a ganglionic blocker, significantly reduced the power of both arterial pressure and heart rate (P less than 0.05), whereas the primary frequencies of both were unchanged. Prazosin, an alpha 1-blocker, sharply reduced arterial pressure power (P less than 0.05) and increased the power of heart rate (P less than 0.05), demonstrating that it is possible to uncouple arterial pressure oscillations from influences of heart rate. We conclude that the sympathetic limb of the autonomic nervous system is primarily responsible for these oscillations and that vagal influences on the heart partially dampen these rhythms. |
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Authors:
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T P Broten; J E Zehr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 256 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-06-16 Completed Date: 1989-06-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1127-37 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Illinois, Urbana 61801. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activity Cycles* Animals Autonomic Nervous System / physiology* Blood Pressure / drug effects Circadian Rhythm* Dogs Female Heart Rate* / drug effects Hexamethonium Hexamethonium Compounds / pharmacology Male Metoprolol / pharmacology Parasympathetic Nervous System / physiology Prazosin / pharmacology Sympathetic Nervous System / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-15307/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 19216-56-9/Prazosin; 37350-58-6/Metoprolol; 60-26-4/Hexamethonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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