Document Detail

Autonomic involvement in idiopathic premature ventricular contractions.
MedLine Citation:
PMID:  23386255     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate autonomic involvement in different types of idiopathic premature ventricular contractions (PVCs) grouped by heart rate (HR) dependency. METHODS: One hundred and sixty PVC patients and 31 controls were enrolled. Holter ECG was used to evaluate PVC occurrence, and spectral analysis of heart rate variability (HRV) was calculated to represent cardiac autonomic control. PVCs were divided into fast rate-dependent (F-PVC), slow rate-dependent (S-PVC), and HR-independent PVC (I-PVC) based on the relationship between hourly PVC density and hourly HR. HRV among different types of PVCs were compared, and the association between PVC density with HR and HRV were analyzed. Furthermore, autonomic changes assessed by consecutive 5-min HRV in 30 min before PVC episodes were investigated. RESULTS: In 160 subjects, there were 73 F-PVC, 56 S-PVC, and 31 I-PVC. Hourly PVC density was positively associated with sympathetic indice (LF/HF) and negatively related to vagal indices (HF and HFnu) in F-PVC, and this trend was reversed in S-PVC. During 30 min before PVC onset, RR interval and HFnu decreased significantly with LF/HF showing an increasing trend in F-PVC, while in S-PVC both RR interval and HF increased significantly. It was noted that those changes were most evident during the last 5 min before PVC onset. In addition, PVC density in F-PVC was significantly decreased by β-blocker treatment. CONCLUSIONS: HR dependency reflected autonomic modulation of idiopathic PVCs. F-PVC and S-PVC might be facilitated by sympathetic activation and vagal activation, respectively. HR dependency and the related autonomic mechanisms should be considered when treating idiopathic PVCs.
Wenbo He; Zhibing Lu; Mingwei Bao; Lilei Yu; Bo He; Yijie Zhang; Xiaorong Hu; Bo Cui; Bing Huang; Hong Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-6
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  -     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiology, Renmin Hospital of Wuhan University and Cardiovascular Research Institute of Wuhan University, 238 Jiefang Road, Wuchang, 430060, Wuhan, People's Republic of China.
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