Document Detail

Autonomic impairment in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  16155429     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurones, but it is increasingly recognized to be a more disseminated disease. The autonomic nervous system may also be involved. Here we review the literature with specific emphasis on autonomic functions in ALS.
RECENT STUDIES: Ample evidence exists for subclinical dysfunction of cardiovascular, sudomotor, gastrointestinal, salivary and lacrimal regulation, even in early ALS cases. Autonomic disturbances may lead to circulatory collapse or sudden death in respirator dependent patients. Several studies suggest the existence of sympathetic hyperactivity in ALS. We discuss some possible pathophysiological mechanisms of the subtle abnormalities and some clinical and treatment implications.
SUMMARY: The wide range of autonomic involvement, together with results suggesting cognitive and extrapyramidal dysfunction, supports the view that ALS is a multisystem degenerative disease.
Rositsa Baltadzhieva; Tanya Gurevich; Amos D Korczyn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  18     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-12     Completed Date:  2006-03-14     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  487-93     Citation Subset:  IM    
Neurology Department, Tel-Aviv Medical Center and the Sieratzki Chair of Neurology, Tel-Aviv University, Ramat-Aviv, Israel.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications*
Autonomic Nervous System Diseases / etiology*
Cognition Disorders / etiology
Digestive System Physiological Phenomena
Pupil / physiology
Sweat / physiology
Urination / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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