| Autonomic function in patients on continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 9527029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate sympathetic function in the peripheries of patients on chronic ambulatory peritoneal dialysis (CAPD) using noninvasive techniques. DESIGN: Comparison of peripheral blood flow responses in sympathetic vasoconstrictor reflexes in CAPD patients and matched control subjects. SETTING: Tertiary care hospital and research institution. PATIENTS: Twenty-three clinically stable CAPD patients and 23 control subjects matched for age, sex, and drug therapy. MAIN OUTCOME MEASURES: Sympathetic activity assessed from the reductions in hand and foot blood flow induced by a deep breath and by body surface cooling. Cardiac autonomic activity measured by the changes in heart rate produced by deep breathing, a Valsalva maneuver, and standing from lying. RESULTS: A deep breath induced mean decreases in hand blood flow of 65.1% in the patients and 82.8% in their matched controls. Corresponding reductions in the foot were 46.0% and 70.0%. Body surface cooling reduced mean hand blood flow by 50.3% in the patients and 71.8% in the control subjects. Corresponding values in the foot were 26.7% and 43.6%. The differences in response between the patients and their matched control subjects were all significant (p < 0.01). Cardiac autonomic function assessed by standard tests of heart rate variability was significantly impaired in the patients compared with the control subjects in two of the three tests used (p < 0.001). CONCLUSIONS: Cardiovascular autonomic impairment can affect the peripheral circulation as well as the heart in patients on dialysis, and this may have implications for cardiovascular homeostasis. |
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Authors:
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S V Jassal; J A Allen; J F Douglas; R W Stout |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 18 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-05-27 Completed Date: 1998-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: CANADA |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, The Queen's University of Belfast, Northern Ireland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Female Foot / blood supply, innervation Hand / blood supply, innervation Heart / innervation Humans Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Reflex / physiology* Regional Blood Flow Sympathetic Nervous System / physiology* Vasoconstriction / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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