| Autonomic function in elderly uremics studied by spectral analysis of heart rate. | |
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MedLine Citation:
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PMID: 15780106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aging determines an altered response of the autonomic nervous system (ANS) to physiologic stresses. A widespread autonomic damage is well recognized in chronic renal failure (CRF). METHODS: We studied 30 CRF patients, aged 19 to 85 years, who were on bicarbonate hemodialysis. Surface electrocardiogram was recorded on lying and 65 degrees head-up tilt standing positions. A dedicated software, using an autoregressive modeling technique, allowed to calculate power spectral analysis (PSA) of heart rate variability, assessing a low-frequency band in the range 0.03 to 0.15 Hz, and a high-frequency band in the range 0.15 to 0.33 Hz. Low-frequency and high-frequency components are regarded, but not invariably, as specific markers of sympathetic and parasympathetic activities, respectively, and the low-frequency/high frequency ratio as an index of sympathovagal balance. RESULTS: In normal controls, low-frequency band value and low-frequency/high-frequency ratio on standing resulted significantly reduced in the group older than 65 years when compared with those younger than 65 years; an opposite finding was seen in high-frequency band value on standing. In uremic patients, low-frequency band on lying resulted significantly lower only in elderly uremics when compared with elderly controls, whereas low-frequency band on standing was significantly lower in elderly than in younger uremics. Regression analysis showed a significant inverse relationship between aging and most low-frequency band values, especially in uremics. The comparison of linear regression models confirmed that a sympathetic autonomic derangement is greatly present in older uremics, in particular after 50 years of age. CONCLUSION: Our data support assertion that combination of aging and CRF increases the chance of autonomic derangement being present. |
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Authors:
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Rita Di Leo; Giuseppe Vita; Corrado Messina; Vincenzo Savica |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 67 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-22 Completed Date: 2005-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 1521-5 Citation Subset: IM |
Affiliation:
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Clinica Neurologica 2, Department of Neurosciences, Psychiatry and Anaesthesiology, Policlinico Universitario, Messina, Italy. rita_dileo@tin.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Autonomic Nervous System / physiopathology* Female Heart Rate / physiology* Humans Male Middle Aged Posture Regression Analysis Renal Dialysis Uremia / physiopathology* |
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