Document Detail

Autonomic function in Kawasaki disease with myocardial infarction: usefulness of monitoring heart rate variability.
MedLine Citation:
PMID:  12911475     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite anticoagulant therapy, many patients with Kawasaki disease and giant coronary artery aneurysm develop myocardial infarction. These patients have a high risk of sudden death, but the etiology is not clear. We studied autonomic function and the possibility of malignant ventricular arrhythmia through heart rate variability. METHODS: We studied six Kawasaki disease patients with myocardial infarction and 16 normal controls. Heart rate variability was investigated using a 24 h electrocardiogram. We assessed the standard deviation from the mean of the normal R-R intervals (SDNN), the proportion of adjacent R-R intervals with a difference greater than 50 msec (pNN50) and the root-mean square of successive R-R differences as time-domain analysis (rMSSD). We assessed very low-frequency power, low-frequency power (LF), high-frequency power (HF) and the LF/HF ratio in frequency-domain analysis. RESULTS: There was no significant difference in SDNN, but there was a significant difference in pNN50 and rMSSD. Patients with Kawasaki disease showed lower HF and higher LF/HF than normal controls. CONCLUSION: Our findings suggest that patients with Kawasaki disease and myocardial infarction show decreased vagal activity, which could cause malignant arrhythmia.
Yutaka Kikuchi; Yuko Sato; Kou Ichihashi; Hirohiko Shiraishi; Mariko Y Momoi
Related Documents :
25465865 - Precordial qrs amplitude ratio predicts long-term outcome after catheter ablation of el...
22527815 - Transient st segment elevation and left bundle branch block caused by mad-honey poisoning.
7523785 - Influence of acute alpha 1-adrenergic antagonism on heart rate variability in patients ...
21256875 - Implication of substance p in myocardial contractile function during ischemia in rats.
8989115 - Macrophage infiltration predicts restenosis after coronary intervention in patients wit...
21195705 - The association of ghrelin polymorphisms with coronary artery disease and ischemic chro...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  45     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2004-01-29     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  407-9     Citation Subset:  IM    
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autonomic Nervous System / physiopathology
Heart Rate*
Mucocutaneous Lymph Node Syndrome / complications,  physiopathology*
Myocardial Infarction / etiology,  physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Feeding practice of infants and their correlates in urban areas of Beijing, China.
Next Document:  Case-control study of giant coronary aneurysms due to Kawasaki disease.