Document Detail


Autonomic function in Kawasaki disease with myocardial infarction: usefulness of monitoring heart rate variability.
MedLine Citation:
PMID:  12911475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Despite anticoagulant therapy, many patients with Kawasaki disease and giant coronary artery aneurysm develop myocardial infarction. These patients have a high risk of sudden death, but the etiology is not clear. We studied autonomic function and the possibility of malignant ventricular arrhythmia through heart rate variability. METHODS: We studied six Kawasaki disease patients with myocardial infarction and 16 normal controls. Heart rate variability was investigated using a 24 h electrocardiogram. We assessed the standard deviation from the mean of the normal R-R intervals (SDNN), the proportion of adjacent R-R intervals with a difference greater than 50 msec (pNN50) and the root-mean square of successive R-R differences as time-domain analysis (rMSSD). We assessed very low-frequency power, low-frequency power (LF), high-frequency power (HF) and the LF/HF ratio in frequency-domain analysis. RESULTS: There was no significant difference in SDNN, but there was a significant difference in pNN50 and rMSSD. Patients with Kawasaki disease showed lower HF and higher LF/HF than normal controls. CONCLUSION: Our findings suggest that patients with Kawasaki disease and myocardial infarction show decreased vagal activity, which could cause malignant arrhythmia.
Authors:
Yutaka Kikuchi; Yuko Sato; Kou Ichihashi; Hirohiko Shiraishi; Mariko Y Momoi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  45     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2004-01-29     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  407-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Jichi Medical School, Tochigi, Japan. ykikuchii@jichi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Autonomic Nervous System / physiopathology
Female
Heart Rate*
Humans
Male
Mucocutaneous Lymph Node Syndrome / complications,  physiopathology*
Myocardial Infarction / etiology,  physiopathology*

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