| Autonomic function after botulinum toxin type A or B: a double-blind, randomized trial. | |
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MedLine Citation:
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PMID: 16157918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare autonomic effects of botulinum toxin (BTX), we randomized patients with cervical dystonia to receive either BTX-A or BTX-B in a double-blind manner. Efficacy and physiologic questionnaire measures of autonomic function were assessed at baseline and 2 weeks after injection. Patients treated with BTX-B had less saliva production (p < 0.01) and greater severity of constipation (p = 0.037) than those treated with BTX-A, but did not differ in other tests of autonomic functions. |
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Authors:
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R Tintner; R Gross; U F Winzer; K A Smalky; J Jankovic |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 65 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-11-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 765-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Baylor College of Medicine, Houston, TX, USA. rtintner@tmh.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Autonomic Nervous System / drug effects*, physiopathology Autonomic Nervous System Diseases / chemically induced*, physiopathology Botulinum Toxin Type A / administration & dosage, adverse effects* Botulinum Toxins / administration & dosage, adverse effects* Cardiovascular Physiological Phenomena / drug effects Cholinergic Fibers / drug effects*, physiology Dose-Response Relationship, Drug Double-Blind Method Enteric Nervous System / drug effects, physiopathology Female Humans Male Middle Aged Neuromuscular Agents / administration & dosage, adverse effects Presynaptic Terminals / drug effects, physiology Reflex, Pupillary / drug effects, physiology Respiratory Physiological Phenomena / drug effects Salivation / drug effects Torticollis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Botulinum Toxins; 0/Neuromuscular Agents; 0/botulinum toxin type B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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