| Autonomic dysfunction in vitamin B12 deficiency: a heart rate variability study. | |
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MedLine Citation:
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PMID: 9722191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was arranged to examine whether vitamin B12 deficiency may cause autonomic dysfunction. Time-domain and long-term frequency-domain heart rate variability parameters from 12 patients with pernicious anemia were compared to 12 age and sex matched controls. In B12 deficient patient group time-domain parameters; SDNN (100.4 +/- 37.86 vs. 131.91 +/- 26.94, P = 0.05), SDANN (87.00 +/- 37.77 vs. 118.83 +/- 26.22, P = 0.05) SD (39.41 +/- 13.32 vs. 53.41 +/- 15.39, P = 0.0221), rMSSD (21.41 +/- 10.00 vs. 28.5 +/- 8.42, P = 0.046) were significantly lower when compared to controls. Difference in pNN50 between groups were not statistically significant. In B12 deficient patients frequency-domain parameters; total power (23.08 +/- 9.89 vs. 34.75 +/- 9.56, P = 0.0078), low frequency power (13.5 +/- 6.57 vs. 22.75 +/- 7.25, P = 0.0069) and high frequency power (7.58 +/- 4.25 vs. 11.58 +/- 3.80, P = 0.0175) were significantly lower when compared to controls. It was concluded that B12 deficiency may cause autonomic dysfunction. |
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Authors:
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A B Sözen; S Demirel; V Akkaya; H Kudat; T Tükek; M Yeneral; M Ozcan; O Güven; F Korkut |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 71 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-11-20 Completed Date: 1998-11-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 25-7 Citation Subset: IM |
Affiliation:
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University of Istanbul, Istanbul Faculty of Medicine, Cardiovascular Research Center, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia, Pernicious / physiopathology Autonomic Nervous System / physiopathology* Female Heart Rate / physiology* Humans Male Middle Aged Reference Values Time Factors Vitamin B 12 Deficiency / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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