Document Detail

Autonomic dysfunction in Parkinson's disease, tested with a computerized method using a Finapres device.
MedLine Citation:
PMID:  7620298     Owner:  NLM     Status:  MEDLINE    
An automated program using a Finapres device and a personal computer, using a battery of five cardiovascular reflex tests has been developed. This has been used to study cardiovascular autonomic dysfunction in 23 ambulant patients with Parkinson's disease, without disabling fluctuations, and 23 age-matched healthy controls, as a screening method to detect autonomic dysfunction. In one patient only a Finapres signal of insufficient quality due to the tremor excluded subsequent analysis. Heart rate response to forced breathing was abnormal (below the fifth percentile of 124 normals) in six (26.1%) of parkinsonian patients and in one (4.3%) healthy age- and sex-matched control, to standing up four (17.4%) versus none, and to the Valsalva manoeuvre seven (30.4%) versus two (8.7%) respectively. The blood pressure response to standing up was abnormal in two (8.7%) parkinsonian patients and in none of the controls, while the response to sustained handgrip was abnormal in five (21.7%) patients versus one (4.3%) control. Autonomic dysfunction is commonly defined as an abnormal score on two or more of the five tests. Using this arbitrary definition, five patients with Parkinson's disease (= 23%) had cardiovascular autonomic dysfunction, and none of the controls were abnormal.
P M Netten; K de Vos; M W Horstink; W H Hoefnagels
Related Documents :
21095968 - Analysis of human tremor in patients with parkinson disease using entropy measures of s...
9313638 - Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, park...
19476518 - Reduction in qsart and vasoactive intestinal polypeptide expression in the skin of park...
18709668 - High frequency extradural motor cortex stimulation transiently improves axial symptoms ...
10494708 - Quantitative and ultrastructural analysis of inflammatory infiltrates in male pattern a...
1578328 - Ethnic differences on the mmpi overcontrolled-hostility scale.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  5     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Department of Internal Medicine, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autonomic Nervous System Diseases / etiology,  physiopathology*
Blood Pressure Determination / instrumentation*
Exercise / physiology
Fingers / blood supply*
Heart Rate / physiology
Hemodynamics / physiology
Middle Aged
Parkinson Disease / complications,  physiopathology*
Reflex / physiology
Regional Blood Flow / physiology
Valsalva Maneuver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of transcutaneous electrical nerve stimulation (TENS) on autonomic cardiovascular reflexe...
Next Document:  Contribution of alpha- and beta- adrenoceptors and neuropeptide-Y to autonomic dysreflexia.