Document Detail


Autonomic dysfunction in PD: A window to early detection?
MedLine Citation:
PMID:  21529844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It has been suggested that autonomic dysfunction constitutes a biomarker for early detection of the disease process in Parkinson disease (PD). Recent findings based on cardiac sympathetic and striatal dopaminergic imaging in the same patients indicate that this view is overly simple. Although evidence of cardiac sympathetic denervation is associated with other non-motor manifestations such as anosmia, REM behavior disorder, dementia, baroreflex failure, and orthostatic hypotension (OH), across individual patients the severities of OH and of the cardiac sympathetic lesion (indicated by thoracic 6-[(18)F]fluorodopamine PET scanning) are unrelated to the severity of the putamen dopaminergic lesion (indicated by brain 6-[(18)F]fluorodopa PET scanning). Moreover, whereas cases have been reported with neuroimaging evidence of cardiac sympathetic denervation several years before motor onset of PD, in other cases loss of cardiac sympathetic innervation progresses approximately concurrently with the movement disorder or can even occur as a late finding. Bases for independent sympathetic noradrenergic and striatal dopaminergic lesions in Lewy body diseases remain poorly understood. In elderly patients with unexplained OH or other evidence of autonomic failure, it is reasonable for clinicians to look for subtle signs of parkinsonism, such as masked facies, cogwheel rigidity, and shuffling gate.
Authors:
David S Goldstein; Latoya Sewell; Yehonatan Sharabi
Related Documents :
8562994 - Serum ca 242 in pancreatic cancer. comparison with ca 19-9 and cea.
10210574 - Monocyte tissue factor levels in patients with urological tumours: an association betwe...
11602894 - Fluorodeoxyglucose positron emission tomography as an adjunct to carcinoembryonic antig...
18849914 - Oxidative stress in patients with graves' ophthalmopathy: relationship between oxidativ...
1468924 - Temporomandibular arthritis in familial mediterranean fever.
11055654 - Mycobacterium tuberculosis infections after renal transplantation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-27
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  -     ISSN:  1878-5883     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1620, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice.
Next Document:  Respiratory pattern in an adult population of dystrophic patients.