Document Detail


Autonomic dysfunction in 2009 pandemic influenza A (H1N1) virus-related infection: A pediatric comparative study.
MedLine Citation:
PMID:  21482200     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Relationship between respiratory morbidity and influenza virus has been well-documented in infants, whatever their age. However, in spite of severe cardiac and respiratory events of central origin, autonomic dysfunction potentially induced by this virus is poorly understood. We thus explored the autonomic nervous system (ANS) profile of infected infants during the 2009 pandemic influenza disease. METHOD: A group of 10 consecutive infants (5<1year and 5>1year) presenting with nvH1N1 infection was evaluated with heart rate variability (HRV) and spontaneous baroreflex (SBR) through a recording during a 15-minute period of quiet sleep as well as 24h holter monitoring. The same recordings were performed in 10 control subjects, paired for gestational and postnatal age. HRV sympathetic and parasympathetic (VLF, LF and HF) indices were obtained using spectral-domain analysis, and spontaneous baroreflex sensitivity (SBR) using simultaneous non-invasive continuous measure of arterial pressure and heart rate. RESULTS: The group of infants less than 1year had similar value as control group. Conversely, the group of infants more than 1year showed significant lower spectral total power values (Ptot: 3347 vs. 5926ms(2)/Hz, p<0.1) and significant lower VLF, LF and HF indices (all p<0.05) than the control group. CONCLUSION: nvH1N1 infection in child could be associated with severe central autonomic dysfunction. Due to potential severe consequences, a systematic evaluation of autonomic regulation should be performed in order to avoid dramatic events.
Authors:
Jérôme Mattéi; Georges Teyssier; Vincent Pichot; Jean-Claude Barthélémy; Emilie Achour; Sylvie Pillet; Thomas Bourlet; Hugues Patural
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-7
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  -     ISSN:  1872-7484     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Paediatric Department, Intensive Care and Neonatology Unit, University Hospital of Saint-Etienne, PRES Lyon, 42055 Saint-Etienne, Cedex 02, France.
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