| Autonomic dysfunction affects cerebral neurovascular coupling. | |
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MedLine Citation:
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PMID: 21796357 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Autonomic failure (AF) affects the peripheral vascular system, but little is known about its influence on cerebrovascular regulation. Patients with familial amyloidotic polyneuropathy (FAP) were studied as a model for AF. METHODS: Ten mild (FAPm), 10 severe (FAPs) autonomic dysfunction FAP patients, and 15 healthy controls were monitored in supine and sitting positions for arterial blood pressure (ABP) and heart rate (HR) with arterial volume clamping, and for blood flow velocity (BFV) in posterior (PCA) and contralateral middle cerebral arteries (MCA) with transcranial Doppler. Analysis included resting BFV, cerebrovascular resistance parameters (cerebrovascular resistance index, CVRi; resistance area product, RAP; and critical closing pressure, CrCP), and neurovascular coupling through visually evoked BFV responses in PCA (gain, rate time, attenuation, and natural frequency). RESULTS: In non-stimulation conditions, in each position, there were no significant differences between the groups, regarding HR, BP, resting BFV, and vascular resistance parameters. Sitting ABP was higher than in supine in the three groups, although only significantly in controls. Mean BFV was lower in sitting in all the groups, lacking statistical significance only in FAPs PCA. CVRi and CrCP increased with sitting in all the groups, while RAP increased in controls but decreased in FAPm and FAPs. In visual stimulation conditions, FAPs comparing to controls had a significant decrease of natural frequency, in supine and sitting, and of rate time and gain in sitting position. INTERPRETATION: These results demonstrate that cerebrovascular regulation is affected in FAP subjects with AF, and that it worsens with orthostasis. |
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Authors:
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Elsa Azevedo; Pedro Castro; Rosa Santos; João Freitas; Teresa Coelho; Bernhard Rosengarten; Ronney Panerai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: Clinical autonomic research : official journal of the Clinical Autonomic Research Society Volume: - ISSN: 1619-1560 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106549 Medline TA: Clin Auton Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurology, Hospital São João, Faculty of Medicine of University of Porto, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal, elsaazevedo@netcabo.pt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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