| Autonomic boundary conditions for ventricular fibrillation and their implications for a novel defibrillation technique. | |
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MedLine Citation:
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PMID: 22893479 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The sympathetic and parasympathetic divisions of the autonomic nervous system modulate cardiac rhythm and the probability of arrhythmia occurrence. Both increased sympathetic drive and hypoxia increase the likelihood for ventricular fibrillation (VF). Vagus nerve stimulation (VNS) can protect from fatal arrhythmias via cholinergic and nitrergic action. We sought to determine boundary conditions for VF and defibrillation by autonomic manipulations accompanied or not by hypoxic changes in urethane-anesthetized rats. VF was induced with (1) vagotomy, (2) systemic high-dose (>15 mg/kg) isoproterenol, and (3) hypoxemia. When VNS (50 Hz) produced cardiac standstill, it converted every VF episode (59/59). A nitric oxide synthase inhibitor did not reduce VNS efficacy (13/14 episodes converted), but addition of atropine reduced VNS efficacy (11/27 episodes converted). VF can be induced by autonomic derangements only under constrained conditions, including sympathetic over-activation, reduced parasympathetic input, and hypoxemia. VNS can provide an alternative method to defibrillate via its cholinergic action. |
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Authors:
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Isaac Naggar; Sae Uchida; Haroon Kamran; Jason Lazar; Mark Stewart |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-15 |
Journal Detail:
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Title: The journal of physiological sciences : JPS Volume: - ISSN: 1880-6562 ISO Abbreviation: J Physiol Sci Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262417 Medline TA: J Physiol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 31, Brooklyn, NY, 11203, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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