Document Detail

Autonomic blockade and the cardiovascular and catecholamine response to electroshock.
MedLine Citation:
PMID:  319704     Owner:  NLM     Status:  MEDLINE    
From a study on the interrelationship between electroshock-induced convulsions, autonomic function, catecholamines, and cardiovascular homeostasis in dogs, the authors found that: (1) the asystole of electroshock (ES) was significnatly prolonged by high spinal anesthesia but not by relative alpha- or beta-adrenergic blockade; (2) increased levels of circulating catecholamines were solely responsible for the marked hypertensive response to ES, since the pressor effect could be blocked by preventing the release of catecholamines with high spinal anesthesia or by inhibiting alpha-adrenergic receptors with phenoxybenzamine; (3) the adrenal medulla appeared to be the source of most of the ES-induced increase in circulating catecholamines; (4) the asystole and arrhythmias of ES were a cholinergic effect, since they were blocked by atropine; (5) there was a dose-response relationship between the coulombs of electricity administered and the catecholamine and cardiovascular responses; and (6) that the adverse cardiovascular effects of ES therapy could be ameliorated pharmacologically.
A H Anton; D S Uy; C L Redderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  56     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:    1977 Jan-Feb
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-54     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Spinal
Atropine / pharmacology
Autonomic Nervous System / drug effects*
Blood Pressure / drug effects
Catecholamines / physiology*
Chlorisondamine / pharmacology
Electroshock / adverse effects*
Heart Arrest / etiology,  physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Phenoxybenzamine / pharmacology
Propranolol / pharmacology
Seizures / etiology,  physiopathology
Tetracaine / pharmacology
Time Factors
Reg. No./Substance:
0/Catecholamines; 51-55-8/Atropine; 525-66-6/Propranolol; 59-96-1/Phenoxybenzamine; 7701-62-4/Chlorisondamine; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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