| Autonomic and behavioral responses of selectively bred hypercholinergic rats to oxotremorine and diisopropyl fluorophosphate. | |
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MedLine Citation:
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PMID: 7938125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypercholinergic Flinders Sensitive Line (FSL) rat was significantly more sensitive than the Flinders Resistant Line (FRL) rat to the biotelemetrically recorded hypothermic effects of oxotremorine, a direct-acting muscarinic agonist, and diisopropyl fluorophosphate (DFP), an anticholinesterase agent. The effects of these agents on heart rate and motor activity, also recorded biotelemetrically, indicate either small differences (DFP) or no significant effect (oxotremorine) between the lines. These findings confirm the dramatic differences in temperature responses to cholinergic compounds between FSL and FRL rats, for which they were selectively bred, but suggest that a general increase in the sensitivity of the FSL rats to all muscarinic-mediated responses may not occur. |
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Authors:
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A H Rezvani; D H Overstreet; A Ejantkar; C J Gordon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 48 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-11-04 Completed Date: 1994-11-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 703-7 Citation Subset: IM |
Affiliation:
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Skipper Bowles Center for Alcohol Studies, Chapel Hill, NC 27599-7175. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autonomic Nervous System / drug effects* Behavior, Animal / drug effects* Body Temperature / drug effects Circadian Rhythm / physiology Heart Rate / drug effects Isoflurophate / pharmacology* Male Motor Activity / drug effects Oxotremorine / pharmacology* Parasympathetic Nervous System / physiology* Rats Species Specificity |
| Chemical | |
Reg. No./Substance:
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55-91-4/Isoflurophate; 70-22-4/Oxotremorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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