Document Detail


Autonomic function during closed loop stimulation and fixed rate pacing: heart rate variability analysis from 24-hour Holter recordings.
MedLine Citation:
PMID:  19889189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Aim of this retrospective study was to analyze the effect of closed-loop stimulation (CLS) and DDD pacing mode on autonomic balance, and to evaluate heart rate variability (HRV) during CLS stimulation. METHODS AND MATERIALS: Autonomic balance was estimated by a 24-hour HRV analysis of paced and spontaneous beats in patients implanted with a dual-chamber pacemaker (Inos(2+) CLS-Biotronik GmbH, Berlin, Germany) and randomly assigned to CLS or DDD pacing mode. Patients underwent two 24-hour electrocardiogram Holter recordings at the end of each 3-month pacing mode period. Each Holter recording was automatically scanned to extract sequences of consecutive beats of the same type [atrial paced (Ap)-sequence and atrial spontaneous (As)-sequence], lasting at least 130 beats. RESULTS: Eight hundred and ten sequences were extracted from 15 patients, and the following spectral parameters were evaluated during both CLS and DDD mode: the total power (variance), the absolute and percentage (relative to the total power) powers of the low frequency (LF, 0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) components, as well as the LF/HF power ratio. DISCUSSION: The two main findings of this study were: in all the patients, CLS seems to mimic short-term physiological HRV, although the variability (total power) was lower than that relative to the spontaneous beats; the HRV of the spontaneous beats had an higher LF/HF when the pacemaker was programmed as DDD respect to CLS, consistent with a shift toward sympathetic predominance.
Authors:
Raffaele Quaglione; Giovanni Calcagnini; Federica Censi; Fabrizio Piccirilli; Luca Iannucci; Marco Raveggi; Gianluca Biancalana; Pietro Bartolini
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-11-04
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  33     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Affiliation:
Istituto del Cuore e dei Grossi Vasi "Attilio Reale," 1a Facoltà di Medicina e Chirurgia, Università di Roma "La Sapienza," Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autonomic Nervous System / physiology*
Cardiac Pacing, Artificial / methods*
Cross-Over Studies
Electrocardiography, Ambulatory*
Female
Heart Rate / physiology*
Humans
Male
Middle Aged
Pacemaker, Artificial
Retrospective Studies
Signal Processing, Computer-Assisted
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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