Document Detail


Autonomic effects of exercise-based cardiac rehabilitation.
MedLine Citation:
PMID:  20861747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: One hypothesis by which exercise-based cardiac rehabilitation (CR) reduces mortality and cardiac events in patients with coronary artery disease invokes a beneficial effect of exercise on autonomic modulation. This study aimed to evaluate the autonomic effects of CR in patients with coronary artery disease.
METHODS: Participants referred to phase 2 CR underwent 4 bicycle stress tests, 2 before starting CR and 2 after. On visits 1 and 3, a symptom-limited bicycle stress test was performed. On visits 2 and 4, the subject exercised to the same workload, but atropine was administered during maximal exercise to achieve parasympathetic blockade. Parasympathetic effect in exercise recovery was computed before and after CR. Heart rate variability for each segment was also quantified. Plasma catecholamine levels were obtained at baseline, peak exercise, and during recovery.
RESULTS: Seventeen subjects (age 56 ± 10 years; 4 women) were enrolled. Six completed the post-CR testing. There was a significant increase in parasympathetic effect during exercise recovery post-CR (P < .001). There was also a significant increase in heart rate variability during exercise recovery post-CR (P < .001). Resting catecholamine levels were not different pre- and post-CR (NS). Post-CR, there was a blunted increase in peak exercise plasma catecholamine levels compared with those seen pre-CR, but this was not statistically significant.
CONCLUSIONS: We demonstrated a shift toward increased parasympathetic and possibly, blunted sympathetic effect in this cohort after completion of an exercise-based CR program. Our findings provide insight into the mechanism for the observed changes in exercise parameters following exercise training, and the improved outcomes seen after CR.
Authors:
Susan T Laing; Ty J Gluckman; Kenneth M Weinberg; Marc K Lahiri; Jason Ng; Jeffrey J Goldberger
Related Documents :
8605517 - Effects of multibuffer supplementation on acid-base balance and 2,3-diphosphoglycerate ...
12481937 - Combined oral contraceptives do not influence post-exercise hypotension in women.
8479307 - State anxiety and ambulatory blood pressure following resistance exercise in females.
21046917 - Effect of different musical tempo on post-exercise recovery in young adults.
17133287 - Acceptability of power variation during a simulated hilly time trial.
21563147 - Withdrawn: exercise for treating anterior cruciate ligament injuries in combination wit...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of cardiopulmonary rehabilitation and prevention     Volume:  31     ISSN:  1932-751X     ISO Abbreviation:  J Cardiopulm Rehabil Prev     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-07-01     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101291247     Medline TA:  J Cardiopulm Rehabil Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Autonomic Pathways / physiology*
Coronary Artery Disease / physiopathology*,  rehabilitation*
Exercise / physiology*
Exercise Therapy / methods*
Female
Heart Rate / physiology
Humans
Male
Middle Aged
Prospective Studies
Young Adult
Grant Support
ID/Acronym/Agency:
1 RO1 HL 70179-01A2/HL/NHLBI NIH HHS; M01 RR-00048/RR/NCRR NIH HHS; R01 HL070179/HL/NHLBI NIH HHS; R01 HL070179-01A2/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early fasciotomy in electrically injured patients as a marker for injury severity and deep venous th...
Next Document:  Impact of cardiac rehabilitation on the ability of elderly cardiac patients to perform common househ...