| Automatic real-time detection of myocardial ischemia by epicardial accelerometer. | |
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MedLine Citation:
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PMID: 19717169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Myocardial ischemia may be detected with epicardial accelerometers. We developed and tested automated algorithms for real-time detection of myocardial ischemia by accelerometer measurements in both experimental and clinical settings. METHODS: In 10 pigs, an accelerometer was fixed to the epicardium in the area perfused by left anterior descending coronary artery. Acceleration and electrocardiogram were simultaneously recorded, and the QRS complex was automatically detected for exact timing of systole. Peak circumferential velocity and displacement were automatically calculated from epicardial acceleration signal within 150 milliseconds after peak R on electrocardiography. Global myocardial function was reduced by esmolol infusion, and regional function was altered by temporary left anterior descending occlusion. Automated ischemia detection analyses were tested in 7 patients during off-pump coronary artery bypass grafting. Left anterior descending coronary artery was occluded for 3 minutes before grafting. In both models, echocardiographic myocardial circumferential strain was used to confirm ischemia. RESULTS: Systolic displacement changed most during left anterior descending occlusion. Negative displacement during ischemia was found in pigs (11.5 +/- 2.3 to -1.2 +/- 2.8 mm, P < .01); regional hypokinesia was found in clinical study (12.8 +/- 8.1 to 3.5 +/- 4.4 mm, P < .01). Ischemia was confirmed by echocardiography in both settings. Esmolol infusion induced smaller changes in automated accelerometer measurements than did left anterior descending occlusion (P < .01). CONCLUSIONS: Automatic real-time detection of myocardial ischemia with epicardial accelerometer was feasible. Automated ischemia detection analysis may be used for continuous monitoring of myocardial ischemia during cardiac surgery. |
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Authors:
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Per Steinar Halvorsen; Espen W Remme; Andreas Espinoza; Helge Skulstad; Runar Lundblad; Jacob Bergsland; Lars Hoff; Kristin Imenes; Thor Edvardsen; Ole Jakob Elle; Erik Fosse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-29 |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 139 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-05-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1026-32 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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The Interventional Centre, Rikshospitalet University Hospital, NO-0027 Oslo, Norway. per.steinar.halvorsen@rikshospitalet.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Disease Models, Animal Echocardiography Electrocardiography Female Humans Kinetocardiography / methods* Male Middle Aged Models, Animal Myocardial Ischemia / diagnosis* Pericardium Swine Systole |
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