Document Detail

Automatic p wave analysis over 24 hours in patients with paroxysmal or persistent atrial fibrillation.
MedLine Citation:
PMID:  17970956     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with atrial fibrillation (AF) often exhibit abnormalities of P wave morphology during sinus rhythm. We examined a novel method for automatic P wave analysis in the 24-hour-Holter-ECG of 60 patients with paroxysmal or persistent AF and 12 healthy subjects. METHODS: Recorded ECG signals were transferred to the analysis program where 5-10 P and R waves were manually marked. A wavelet transform performed a time-frequency decomposition to train neural networks. Afterwards, the detected P waves were described using a Gauss function optimized to fit the individual morphology and providing amplitude and duration at half P wave height. RESULTS: >96% of P waves were detected, 47.4 +/- 20.7% successfully analyzed afterwards. In the patient population, the mean amplitude was 0.073 +/- 0.028 mV (mean variance 0.020 +/- 0.008 mV(2)), the mean duration at half height 23.5 +/- 2.7 ms (mean variance 4.2 +/- 1.6 ms(2)). In the control group, the mean amplitude (0.105 +/- 0.020 ms) was significantly higher (P < 0.0005), the mean variance of duration at half height (2.9 +/- 0.6 ms(2)) significantly lower (P < 0.0085). CONCLUSIONS: This method shows promise for identification of triggering factors of AF.
Alexander Bitzen; Karsten Sternickel; Thorsten Lewalter; Jörg Otto Schwab; Alexander Yang; Jan Wilko Schrickel; Markus Linhart; Christian Wolpert; Werner Jung; Peter David; Berndt Lüderitz; Georg Nickenig; Lars Lickfett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  12     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-31     Completed Date:  2008-01-24     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-15     Citation Subset:  IM    
Department of Medicine--Cardiology, University of Bonn, Bonn, Germany.
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MeSH Terms
Atrial Fibrillation / physiopathology*
Case-Control Studies
Electrocardiography, Ambulatory*
Middle Aged
Signal Processing, Computer-Assisted
Statistics, Nonparametric
Time Factors

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