| Automatic control of the inspired oxygen fraction in preterm infants: a randomized crossover trial. | |
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MedLine Citation:
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PMID: 15347564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In preterm infants receiving supplemental oxygen, manual control of the inspired oxygen fraction is often time-consuming and inappropriate. We developed a system for automatic oxygen control and hypothesized that this system is more effective than routine manual oxygen control in maintaining target arterial oxygen saturation levels. We performed a randomized controlled crossover clinical trial in 12 preterm infants receiving nasal continuous positive airway pressure and supplemental oxygen. Periods with automatic and routine manual oxygen control were compared with periods of optimal control by a fully dedicated person. The median (range) percentage of time with arterial oxygen saturation levels within target range (87-96%) was 81.7% (39.0-99.8) for routine manual oxygen control, 91.0% (41.4-99.3) for optimal control, and 90.5% (59.0-99.4) for automatic control (ANOVA: p = 0.01). Pairwise post hoc comparisons revealed a statistically significant difference between automatic and routine manual oxygen control (Dunnett's test: p = 0.02). The frequency of manual oxygen adjustments was lowest in automatic control (Friedman's test: p < 0.001). Automatic oxygen control may optimize oxygen administration to preterm infants receiving nasal continuous positive airway pressure and reduce nursing time spent with oxygen control. |
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Authors:
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Michael S Urschitz; Werner Horn; Andreas Seyfang; Antonella Hallenberger; Tina Herberts; Silvia Miksch; Christian Popow; Ingo Müller-Hansen; Christian F Poets |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2004-09-03 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 170 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-09 Completed Date: 2004-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1095-100 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatology, Tuebingen University Hospital, Tuebingen, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Automation Cross-Over Studies Female Follow-Up Studies Humans Infant, Newborn Infant, Premature* Male Oxygen / therapeutic use Oxygen Consumption / physiology* Oxygen Inhalation Therapy / methods* Positive-Pressure Respiration / methods* Probability Pulmonary Gas Exchange Reference Values Respiratory Distress Syndrome, Newborn / diagnosis, therapy* Respiratory Function Tests Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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