Document Detail

Automatic control of airway pressure for treatment of obstructive sleep apnea.
MedLine Citation:
PMID:  8582718     Owner:  NLM     Status:  MEDLINE    
Obstructive sleep apnea (OSA) occurs when airflow ceases because of pharyngeal wall collapse in sleep. Repeated apneic events results in the development of a pathological condition called OSA syndrome. We describe the methodology and design of a prosthetic device, named automatic positive airway pressure (APAP), for treatment of this syndrome. APAP applies a stream of air via a nasal mask at an initial pressure selected by the patient. By sensing specific pressure characteristics of air flow immediately preceding pharyngeal wall collapse, the APAP device automatically raises the applied pressure to maintain a patent upper airway and thus prevent apnea. Conversely, when such conditions are absent, pressure is lowered step wise until a preselected minimum pressure is reached. Performance evaluation of the APAP system in five OSA patients and five normal (asymptomatic for sleep apnea) subjects revealed that it effectively treated OSA syndrome. It lowered the apnea-hypopnea index without disturbing sleep and resulted in a lower mean airway pressure compared to the traditional continuous positive airway pressure (CPAP) therapy. The results also show that the pressure needed to prevent OSA varied significantly throughout the night. For OSA syndrome patients, this pressure ranged from 3 to 18 cm H2O. The mean airway pressure for these patients had a sample average of 6.80 cm H2O and a standard deviation of 3.17 cm H2O. In normal subjects, the device did not raise pressure except in response to Pharyngeal Wall Vibration events.
K Behbehani; F C Yen; J R Burk; E A Lucas; J R Axe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  42     ISSN:  0018-9294     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-20     Completed Date:  1996-03-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1007-16     Citation Subset:  IM    
Department of Biomedical Engineering, University of Texas at Arlington 76019, USA.
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MeSH Terms
Air Pressure
Bronchi / physiopathology*
Equipment Design
Evaluation Studies as Topic
Positive-Pressure Respiration / instrumentation*,  statistics & numerical data
Reference Values
Sleep Apnea Syndromes / physiopathology,  therapy*
Grant Support
1 R15 HL 46467-02/HL/NHLBI NIH HHS

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