Document Detail

Automatic CPAP titration with different self-setting devices in patients with obstructive sleep apnoea.
MedLine Citation:
PMID:  15332397     Owner:  NLM     Status:  MEDLINE    
Autotitrating continuous positive airway pressure (CPAP) devices automatically adjust the pressure according to upper airway obstructions. The aim of this study was to compare the treatment effects of different automatic CPAP devices (AutoSet, Horizon and Virtuoso) with conventional CPAP in patients with obstructive sleep apnoea independently of financial manufacturer support. Twelve male patients with obstructive sleep apnoea were submitted to a crossover study protocol with overnight polysomnography for 6 consecutive nights. After diagnostic polysomnography, the CPAP pressure was manually titrated. Over the next 4 nights, the patients were treated with any one of the three automatic CPAP devices or fixed CPAP in random order. The apnoea/hypopnoea index on the diagnostic night was 67.3+/-21.7 events h(-1), and was significantly reduced to 0.7+/-1.2, 3.0+/-2.9, 2.3+/-2.5 and 12.0+/-13.6 events x h(-1) with the fixed CPAP, AutoSet, Horizon and Virtuoso devices respectively. An apnoea/ hypopnoea index of <5 events h(-1), an indicator of optimal treatment, was achieved in all patients with fixed CPAP and in 10 patients using the Autoset and Horizon devices, but in only six of the 12 using the Virtuoso. The mean pressure was significantly lower with the AutoSet and Virtuoso devices, but not with the Horizon as compared to fixed CPAP. The maximum pressure was significantly higher with the Horizon. It is concluded that automatic continuous positive airway pressure devices produce a significant reduction in apnoea/hypopnoea index; however, there is considerable difference in the efficacy of the various devices.
A Stammnitz; A Jerrentrup; T Penzel; J H Peter; C Vogelmeier; H F Becker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European respiratory journal     Volume:  24     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-11-30     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Dept of Respiratory Medicine & Sleep Unit, Philipps University Marburg, Marburg an der Lahn, Germany.
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MeSH Terms
Continuous Positive Airway Pressure / instrumentation*,  methods
Cross-Over Studies
Equipment Design
Equipment Safety
Follow-Up Studies
Middle Aged
Oxygen Consumption / physiology
Prospective Studies
Risk Assessment
Severity of Illness Index
Sleep Apnea, Obstructive / diagnosis,  therapy*
Statistics, Nonparametric
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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