| Automatic 3D registration of dynamic stress and rest (82)Rb and flurpiridaz F 18 myocardial perfusion PET data for patient motion detection and correction. | |
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MedLine Citation:
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PMID: 22047396 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: The authors aimed to develop an image-based registration scheme to detect and correct patient motion in stress and rest cardiac positron emission tomography (PET)/CT images. The patient motion correction was of primary interest and the effects of patient motion with the use of flurpiridaz F 18 and (82)Rb were demonstrated.Methods: The authors evaluated stress/rest PET myocardial perfusion imaging datasets in 30 patients (60 datasets in total, 21 male and 9 female) using a new perfusion agent (flurpiridaz F 18) (n = 16) and (82)Rb (n = 14), acquired on a Siemens Biograph-64 scanner in list mode. Stress and rest images were reconstructed into 4 ((82)Rb) or 10 (flurpiridaz F 18) dynamic frames (60 s each) using standard reconstruction (2D attenuation weighted ordered subsets expectation maximization). Patient motion correction was achieved by an image-based registration scheme optimizing a cost function using modified normalized cross-correlation that combined global and local features. For comparison, visual scoring of motion was performed on the scale of 0 to 2 (no motion, moderate motion, and large motion) by two experienced observers.Results: The proposed registration technique had a 93% success rate in removing left ventricular motion, as visually assessed. The maximum detected motion extent for stress and rest were 5.2 mm and 4.9 mm for flurpiridaz F 18 perfusion and 3.0 mm and 4.3 mm for (82)Rb perfusion studies, respectively. Motion extent (maximum frame-to-frame displacement) obtained for stress and rest were (2.2 ± 1.1, 1.4 ± 0.7, 1.9 ± 1.3) mm and (2.0 ± 1.1, 1.2 ±0 .9, 1.9 ± 0.9) mm for flurpiridaz F 18 perfusion studies and (1.9 ± 0.7, 0.7 ± 0.6, 1.3 ± 0.6) mm and (2.0 ± 0.9, 0.6 ± 0.4, 1.2 ± 1.2) mm for (82)Rb perfusion studies, respectively. A visually detectable patient motion threshold was established to be ≥2.2 mm, corresponding to visual user scores of 1 and 2. After motion correction, the average increases in contrast-to-noise ratio (CNR) from all frames for larger than the motion threshold were 16.2% in stress flurpiridaz F 18 and 12.2% in rest flurpiridaz F 18 studies. The average increases in CNR were 4.6% in stress (82)Rb studies and 4.3% in rest (82)Rb studies.Conclusions: Fully automatic motion correction of dynamic PET frames can be performed accurately, potentially allowing improved image quantification of cardiac PET data. |
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Authors:
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Jonghye Woo; Balaji Tamarappoo; Damini Dey; Ryo Nakazato; Ludovic Le Meunier; Amit Ramesh; Joel Lazewatsky; Guido Germano; Daniel S Berman; Piotr J Slomka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical physics Volume: 38 ISSN: 0094-2405 ISO Abbreviation: Med Phys Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425746 Medline TA: Med Phys Country: United States |
Other Details:
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Languages: eng Pagination: 6313 Citation Subset: IM |
Affiliation:
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Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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